ID A0A1C7M161_GRIFR Unreviewed; 4995 AA.
AC A0A1C7M161;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN Name=MDN1 {ECO:0000313|EMBL:OBZ68834.1};
GN ORFNames=A0H81_11204 {ECO:0000313|EMBL:OBZ68834.1};
OS Grifola frondosa (Maitake) (Polyporus frondosus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Grifolaceae; Grifola.
OX NCBI_TaxID=5627 {ECO:0000313|EMBL:OBZ68834.1, ECO:0000313|Proteomes:UP000092993};
RN [1] {ECO:0000313|EMBL:OBZ68834.1, ECO:0000313|Proteomes:UP000092993}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9006-11 {ECO:0000313|EMBL:OBZ68834.1,
RC ECO:0000313|Proteomes:UP000092993};
RA Min B., Park H., Kim J.-G., Cho H., Oh Y.-L., Kong W.-S., Choi I.-G.;
RT "Whole genome sequencing of Grifola frondosa 9006-11.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBZ68834.1}.
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DR EMBL; LUGG01000019; OBZ68834.1; -; Genomic_DNA.
DR STRING; 5627.A0A1C7M161; -.
DR OMA; ILEQWHR; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000092993; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 7.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 2.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000092993}.
FT DOMAIN 4772..4992
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 780..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4122..4616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4154..4188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4202..4218
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4219..4243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4252..4290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4291..4307
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4348..4367
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4463..4489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4499..4518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4524..4538
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4541..4562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4586..4607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4995 AA; 557011 MW; BBF92CA46321BC86 CRC64;
MERSFDFHDP LSLNLKRQSA RLIAEFPNQN DLAAALQYAS SRAELLDILS QLLSQPQYTS
AVASAFRPIL LDLCARWLHD DERRDEKLEA LCFLLEIHPE LYPLLALFVS RPGYELGPLA
FVCTCPVPSL DRIRLHCLLL AYYRLLEANR ILSRTLSWPL APLSKLIWTP HPDPGVRLLA
IRCYALHAGM METERVKMEK EAIGDVSEVD CPISYSVDRD GCRQEVDGWL LPVIEAKRVV
DSRNALLDPQ EYFGTDEEPI QPSELSPLIA NVHGILLLRS SISTSQYSLL VHTPTTVQSL
RSLAVQISLR VPTLLTSAPS AGKSLLLSHL VQMLRSNIHT ALVTIHLADT SLDARALLGS
YVSSPSRPGS FEWADGVLVR AMRAGAWVML EDVDRASSEV LGVLKPLVES LGADGWIGAR
AVIDVPGRGR VEAEEGFAIF ATRSVVPGRS GSFPAPAFFG AHKFYEVIIP SPTEDDLKMI
VDAKFPRLIG AAARGLIAMW EAVRGLGSTS STREVGIREL EKLCARVESL LPSFHQSMDV
DTILAPLSSV FPNPTLREDI YLEARDVFFG SGATTTSARS YVDSCARVVA EHLGLSPERR
DWLLNTRTPE LEVERDVDRR TVAVRAGRTR LLARTSKSEI APPVARPFAM HRPAVCLLSR
IASAVSLGEP VLLTGETGTG KTSIVTHLAG LLRRRLISLN LSNQTESSDI VGGFKPVDAR
MPGMELQERF LELFGGTFSR KKNAHFEESV RRAVREGKWK RATGLWLESV RLAKERIRAH
GTQDEEKELQ TGGETPRKRR KVDMGSLKVS EASWEVFERD VQSFAIQHVQ GKSKFAFAFV
EGPLVRALRS GDWILLDEVN LASPETLECI AGLLHGPTAS IILTEQGSLE PVPRHPDFRL
FACMNPATDV GKKDLPPRIR SRFTEIDVPP PDADKDTLLS IVAQYIGSCA VGDRGTIMDV
AEFYSAVKQL ADARQIADGA NHRPHYSMRT LARALTFAAD MTSAYSLRRA LWEGCLMAFT
MVLDGPSAAA VSALAQKHLL AGVRNPRSLL SKDPSPPANP DAFIKLGPFY LQKGPLPEDL
VDDYIMTPSV ETKVIDLARI ISAKRFPVLI EGPTSSGKTS SIEYLAKRTG HRFVRINNHE
HTDIQEYLGT YVSDAVTGKL VFKDGLLVRA LRNGDWIVLD ELNLAPTDVL EALNRLLDDN
RELLIPETQE VVRPHPHFML FATQNPPGLY AGRKVLSRAF RNRFLEVHFE DVPQAELETI
LCQRCKIAPS YGQKIVSVFR ELQKRRQSSR VFESKHGFAT LRDLFRWAGR DALGYQELAA
NGYMLLAERA RREDDKAVVK EVIESIMKVN IDEKTLYDLR GSSVDFPSFL HCPIPSSSQV
VWTGAMQRLF ILVGRALRFN EPVLLVGETG CGKTSVCQLY AEVLSRTLRT VNCHQNTETA
DLIGGLRPIR NRAVVEAEVL QEATSALERI GVTNVNRNAS SLFSSIVEVL KSRSLNSEEV
TAWRSLQSRL QRLSAMFEWC DGPLIEAMRN GDVFLLDEIS LADDSVLERL NSVLEPERTV
VLAERGGDDV QLPSLSPALR NRFTEIWVPS ITDRRDLECI VENLWHHEAL RVHTGPLLDF
VEWLSSVVAD RSVLSLRDIL AWVAFSNATF RADLSEGISV NEIFHHAAHM TFLDGLGSLP
QLSAYSRDAM EKLKLQAEGK LQEVAPLLGS SDYAPESDPS TNVQLGIFSV PRGPKEPAPH
TFSLQAPTTC DNVMRVVRAC QLPKPILLEG SPGVGKTSLV AALANFCGYE LCRINLSDQT
DLVDLFGSDL PVEGGDPGQF AWKDAEFLRA LQMGHWVLLD EMNLAPQAVL EGLNAVLDHR
GTVYIPELGR SFARHPSFRI FAAQNPLHQG GGRKGLPKSF LNRFTKVYVQ EMTSDDLLLI
CRNLFPVYRP EFLRGMITYA TYLNEETMIK RTFAREGSPW EFNLRDVLRW ATLLQHPGPS
DHPSQYLSQI FLQRFRTRVD REQALLLFDK IFSHNGKQES PSFTISSSFL QVGHLVTSRA
GHLLDRRCGR LLQAHLPALE AICTCLENAW LTILTGSRDS GKTNLVRLIA NLTGRTLREI
SINHATDATD ILGSFEEIDL SYGVTQLAHN IVALLDDIFG SCGGSKLLVA ARVLDELGDL
PEPWKTRRNA LRNASADLII AHGGTGRLEW VDGPLVRAMS EGHWLLLDGA NLCNASVLDR
LNSLCETDGV LTLNERGAVN GQVQVLKPHP NFRLFMSVDP HYGELSRAMR NRGVEIALVG
IPTSEDSRRL LDHCRLPLAS VTPNTDRKSF IWEFELIRRG VSSMPISCIS SNSRWSIGSL
LSEDCSNSLL ADLAPSLPLT PSITPPLHHR AVLYFIAHCL IPVHLPFLSR FVCALDSPQL
GSNLGTIGTM LSALRDSRVM ASLRLLQDNC GRSCGVPLEI LVSQPVHSPL PHTLVPGKCS
EVDQLSAQLL PALRLFIASK FDFEAPDHSF EESSKMDSRK PAKHGHLTGK SRLLTDAIQA
AARMTLDNMD VAKSGIDILL KLVSFGRCLQ KAATSHSFDF SVVQVVLRWI LEALCDRSDE
FGSIEVHAEA LHAAVSLTSG LGLVELWSSI SPSNSREGSA GEVVRLEKIA YDLQRSHDPQ
NSRSQVLELM ALWMLPQVGS EDDRRRLTTL SKHVERLLPK DLQDCESPMT SELEPALIVT
ELHLLQSISG IDSARLSQDC LSTMSYLLSS GCAGFKNSLS RLVPYKHMIW AIDAGQPRIH
IIANVHKRWL EDVWMTSPIA GIKGPSVLFL PTQVYSTMMY CDPDLRPLTS RNSYERSLDR
RLRLFSTHPV DSTSRFMQTT TFMLQAILMI TACFTEVPGD VSAELGIIDA RTKPITAVHE
LILHMLDNVN HSGFREAYGR HLRFPLVNFM ELCRAGFASL VDLGYCWIAL CRFMLELYVP
DAPLDPAIMR QYSWNFWNEE RALFSTEMQM HIDFENRTNG QTSNPAIQYL SVLMLDAEKH
LGNENMTHPC LQGRDDVTGL HSYWTEVSQF LTHVISPAKI DATISALRSQ DAAASMREHV
VQESLTSFCQ RLSTVYTKYA DISEPLQLAL LYMKFGLRLV ADAVPQTDML QSSQTGVTAA
LVAFPAMRSA EMLRIEAECQ RSSSSSPIFL VAALEGIALE THAGVDIRTF VPEIEKIYEQ
VLGLWMIDRT RKEDSDREAQ SLYRQNSMEH TAVTEAELEE QDFLSIFPQF EDLLEPDASS
DRQAPQRRPL IGQNVPLQLS QVHEHLFAPD FLRVSISNQF MDLRRSFLRT LLDSHFKSTP
ETLDHISQAF QITLLHDRLN EIRGSRLDAK PYNFYVDANV PESGKALAIL QRMSQRLQSL
TRDWPDQMVL QHLKDRCDAI MTLDLRSPVA KVLSSLEQLL LQTEDWEMYA CRDNTLKSYQ
QELTTLIVDW RRLELASWQG LLQTQAHDFS DGAAEYWFRL YEATIRGVLA AVEEETRGRS
QAVEEYLNGL IPLLDEYIRL SPLGQYKTRL RQLGSFETFI NYLSNDHCDI RTATLQRVHR
ILHFTLEYYG AFVPHISAAL ARQQSELEKD IRGFIKLASW KDVNVHALKQ SAQRSHRQLY
KCIRKFRDVL RQPVLAFLQP SSQEVEDISP TQPPVPCLTP ESPHFPGVVN ASVEPSHLVH
LGKTFKKFQS LIMDHFGPGI IRLSPHHVED LSTDIIVAMK DLSSSSIPVK ATSTERRKLE
KSLLVRKRKA WSDLLKELKR VGFAANVKPE ILERQRDPRW LREQPLLIRQ TDGFEAITKG
EDYLYRLANL LPDLRATLSS HHQDLSTREL QRGIMLLESG FTMALDARAC LADALDRYRQ
LRNISLRMSV LASARIRSTG SAMLARVSNT KDNLCKLVHA LEETLLNLRE YEHHQTMPQD
VLTGVQSIID SSRVFSTRIS DGLRDMKLMN SPVLVENEAI LLEQASAHLA GSIDTLRKWS
TELPFSYFFA PLSSWLERFT PWDLTRFPYH PLDSVPDSTN QLINSLLISS QAILSLCPAD
PAVDSSETED RFVRDHHRLI CSLTRSLQLD TLLNQSEGIL VELVQCTEHE RAYRIARFLP
FLDAYLQFIK VQLSNQSDWT KALFKLDYIL CTVVHTVAKQ GFCKPPDMED SGTGEGGTEQ
VDGTGLGDGV GNENVSKDIE DESQVEGLQG EEKAPEEEVE RAEEGNAVEM SEDIGGEMQD
IPDKEEGDEE DADQESELDS EEQLGKLDAT DPSAVDEKLW GDESGPQDPG QDGKTSEDHS
SQKQDSDVVA KEEGNKNPKE SQRNDEEAAP EQGDEQGTED SALEEKVDET EAQDGTALDE
YIQEADTLDL PDDMDMDAGQ EQRELRDDDS DIEMDDAEQE DEIPPSPEQD SLGDQSQDLE
EQLADEIDDT APAVQEEAPP ETKSDETTDA TVIQPDIHVG DSNDGGASTD ASAAAAAAAA
AARDIQPDEG TTSEGQAAGG ASHGDDDSEE PSQHEPSTEK MEGIEDATGR GEDASGTARA
PQGVSSQTNA SQLSSNPLRG LGDALREISR RFEEILDSDD SPEQSTAPQT EPSRTSQMEY
MRPEEFSAND ELQALGPAQQ EEVVKLNDLK FIDDDHTPTE AAAPMEEERS MPEPQGSMLT
SALHAEPTSQ TLGDDVESAL TQTEIRAQLP SQPIDSDQPP MLDAGASPGP GTVSETQYDV
ELKLRQWEAE GQPSRGAENM WRLYESLTHD LSYALCEQLR LILEPSLATR LKGDYRTGKR
LNMKKIIPYI ASEFTKDKIW LRRTRPSQRE YQVLIALDDS RSMAESHSVH LAYQTLALVS
KALGRLEVGD IAIAKFGESV DVLHSFEGGP FTDQAGTKVM NAFHFDQKAT QVLSLVETSL
KLLEQARERR SMTSASASDL WQLEIIISDG ICQDHDRLRT ILRKAEEQRV MIVFIILDSL
HTKGTSQTGQ GTNQNSILSM NQVAYKTVDG RMDLHVERYL DTFPFEYYVV LRDVEALPDV
LSGTLKQFFE RIAES
//
