ID A0A1C7M6X7_GRIFR Unreviewed; 734 AA.
AC A0A1C7M6X7;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Autophagy-related protein 15 {ECO:0000256|ARBA:ARBA00029828};
DE EC=3.1.1.117 {ECO:0000256|ARBA:ARBA00026105};
DE EC=3.1.1.3 {ECO:0000256|ARBA:ARBA00013279};
GN Name=ATG15_1 {ECO:0000313|EMBL:OBZ72129.1};
GN ORFNames=A0H81_08058 {ECO:0000313|EMBL:OBZ72129.1};
OS Grifola frondosa (Maitake) (Polyporus frondosus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Grifolaceae; Grifola.
OX NCBI_TaxID=5627 {ECO:0000313|EMBL:OBZ72129.1, ECO:0000313|Proteomes:UP000092993};
RN [1] {ECO:0000313|EMBL:OBZ72129.1, ECO:0000313|Proteomes:UP000092993}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9006-11 {ECO:0000313|EMBL:OBZ72129.1,
RC ECO:0000313|Proteomes:UP000092993};
RA Min B., Park H., Kim J.-G., Cho H., Oh Y.-L., Kong W.-S., Choi I.-G.;
RT "Whole genome sequencing of Grifola frondosa 9006-11.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-
CC O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+);
CC Xref=Rhea:RHEA:67452, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30879, ChEBI:CHEBI:171667, ChEBI:CHEBI:171668;
CC EC=3.1.1.117; Evidence={ECO:0000256|ARBA:ARBA00024511};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67453;
CC Evidence={ECO:0000256|ARBA:ARBA00024511};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid +
CC H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001024};
CC -!- SUBUNIT: Binds to both phosphatidylinositol (PI) and
CC phosphatidylinositol 3,5-bisphosphate (PIP2).
CC {ECO:0000256|ARBA:ARBA00011137}.
CC -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC {ECO:0000256|ARBA:ARBA00004343}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004343}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004270}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004270}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
CC -!- SIMILARITY: Belongs to the carbohydrate esterase 15 (CE15) family.
CC {ECO:0000256|ARBA:ARBA00010092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBZ72129.1}.
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DR EMBL; LUGG01000009; OBZ72129.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C7M6X7; -.
DR STRING; 5627.A0A1C7M6X7; -.
DR OrthoDB; 1420757at2759; -.
DR Proteomes; UP000092993; Unassembled WGS sequence.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00519; Lipase_3; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002921; Fungal_lipase-like.
DR PANTHER; PTHR47175; LIPASE ATG15-RELATED; 1.
DR PANTHER; PTHR47175:SF2; LIPASE ATG15-RELATED; 1.
DR Pfam; PF01764; Lipase_3; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000092993};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..734
FT /note="Autophagy-related protein 15"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008888963"
FT DOMAIN 234..261
FT /note="Fungal lipase-like"
FT /evidence="ECO:0000259|Pfam:PF01764"
FT COILED 411..448
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 734 AA; 80155 MW; 97EA4952A8DE2485 CRC64;
MLLALTNLLI PLLSIFSREQ TPISVPEVSS APELHFELRH LHAATPSGQI LFHDVHPADS
FIADSQVSYT LRTRHIKSHK PSSFAAFSRA RARSIEFGES EALHWDIEEM IGPDSEDRDT
LLQIAKMTNN AYLEPGEPGW YDLEGKWNVS YPFGWEAEDD SLRGHIFATS DNSTVVLAIK
GTSAAFVGGG GPTSKKDKVN DNLLGGWKCD QNCLEDALIE ENLFYPIGTN LYNNLTYLYP
DSNVWVVGHS LGGALASLLG VTFGIPVVAI ESPGEKMAAA RLHLPSPPSV QHITHLYHTA
DPIAMGTCNG VLSSCALGGY AMESKCHLGS SIIYDTVSNL SWAVDIRTHT IVNVIEKLLA
LPWPPSVEVG REVPEAKPEE DCVECFSWEF GDFPASGRVD VVSGEQYRYA LTNFRIAHEK
VEEQRMQLQE QERQVALLRA RIALLEGTNQ DGQAGAFAME GSNSVDDFSI KNAASNLGRL
MNRWAADIVR APPVPLDQIR DAAVKDLLDG DIPEPNPFTS NTTGMQVQGL LRHAMSQTIS
EGIINCLVIT NCPDANIQLT RIHEHIFSRD ATVAAVWRRQ TFSAAVESCS NEMSRFLLTE
HMAALTATLN IENGKPPASE ALDVLQAAYG FSRMLHGSPS SSGGTVDAFY RAFVPELRGT
LDPQQIELVK RCVKTEHGQS DRVGATVFPG LVKVSRSAAG PSGQENTQTV VKRAQVVCEC
ALGVNTDAQC SEWY
//