ID A0A1C7PA44_9BACT Unreviewed; 584 AA.
AC A0A1C7PA44;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=PYTT_2471 {ECO:0000313|EMBL:SEI00304.1};
OS Akkermansia glycaniphila.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=1679444 {ECO:0000313|EMBL:SEI00304.1, ECO:0000313|Proteomes:UP000176204};
RN [1] {ECO:0000313|Proteomes:UP000176204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Koehorst J.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; LT629973; SEI00304.1; -; Genomic_DNA.
DR RefSeq; WP_067777492.1; NZ_LT629973.1.
DR AlphaFoldDB; A0A1C7PA44; -.
DR STRING; 1679444.PYTT_2471; -.
DR KEGG; agl:PYTT_2471; -.
DR PATRIC; fig|1679444.3.peg.1275; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000176204; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000176204};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..244
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
SQ SEQUENCE 584 AA; 65767 MW; 384CD5E764881877 CRC64;
MLPSSSNRRK RWYDVFSSVP HWIKYALIPL GILLVLFFAV VIVFSWRASQ YDLAHVLDAP
MNSAIYDAEG RCISALDDNE RVNIALADAP QYLVDAFIAR EDERFMEHGG IVYTSVLRSI
LKNISSFSYE QGASTITMQL ARNVFDLRAK TIDRKLLEIA ITKRIEEAYD KKTILAAYLN
RIYFGQDCYG VAQAARTYFG KNVGSLNLSE CATLAGLVRG PSYFNPIRNL KAATRERDAT
LKRMYETGKI SEALYEKTKK EPIVVHRLDK GSYCSYIVMW VIDELESLCG EVGTESSGIR
VHTSLNLPLQ QFMERKCEET LQSLEKNKIW EGLPRRSKGH LDRCVQVAAM CVETRTGNVL
AVIGGRSPQD GQTRWLKEVK PGMAFAPVVN CRASEKQINI IADAPLQTGR ALGHKSVLDA
CARLHLPGNL PESDELYLGE FSLPLIDLAR SLYCIQNRGK YFPLQLIQQV SSFGDTPLYV
NTQQLDAKEV VPREAARNVA SCRPFRTDET NRTMNMNITL PGQDGQWVSM AGRSVTVFLW
LGFDEATPEM YDRKGFKKLL SETAANLAEQ IYTEAKNTLN TKKK
//
