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Entry: A0A1C7PAJ9_9BACT
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ID   A0A1C7PAJ9_9BACT        Unreviewed;       417 AA.
AC   A0A1C7PAJ9;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   13-FEB-2019, entry version 13.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=PYTT_0749 {ECO:0000313|EMBL:SEH78848.1};
OS   Akkermansia glycaniphila.
OC   Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales;
OC   Akkermansiaceae; Akkermansia.
OX   NCBI_TaxID=1679444 {ECO:0000313|EMBL:SEH78848.1, ECO:0000313|Proteomes:UP000176204};
RN   [1] {ECO:0000313|Proteomes:UP000176204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Koehorst J.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
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DR   EMBL; LT629973; SEH78848.1; -; Genomic_DNA.
DR   RefSeq; WP_067776752.1; NZ_LT629973.1.
DR   EnsemblBacteria; OCA02591; OCA02591; AC781_08850.
DR   KEGG; agl:PYTT_0749; -.
DR   PATRIC; fig|1679444.3.peg.939; -.
DR   KO; K01945; -.
DR   OrthoDB; 932854at2; -.
DR   BioCyc; GCF_900097105:G1FN0-753-MONOMER; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000176204; Chromosome i.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000176204};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:SEH78848.1};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000176204}.
SQ   SEQUENCE   417 AA;  44849 MW;  5A87DD0015589A16 CRC64;
     MKIAVIGKGG REHALVETLA NSPCKPEIYS FPGSDAILRI AQPIDAHDLE SLISWMKGNS
     IDLCVAGEES YLVTGEGLAN LCSEAGIPCW GPVKESAQLE ASKEFSKEFL IRHGIPTAKA
     QIASDYDEAK AKIGGTYPTV LKFDGLAAGK GVAVCPDETS ADEFLKEIFI DKRFGPGRLL
     IEECLVGPEI SIFGAIVDDR YMILCPARDY KRLGDGDIGP NTGGMGAVAS RQLADPALLE
     TIERTIVAPT VAGLRKDGLP YRGFLYFGLM LTQDGPKIIE YNCRFGDPEC EAVMPLLRGD
     LASFCLAGAK GEFKPELISF DEGWSVCCIL ASKGYPATSH SGDLISGLSD VTEARIYHCG
     TKLDADGNYL TNGGRVLAIV AQGATLDEAR KRAHTETSKI TFDGAQRRTD IAYRCFE
//
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