ID A0A1C7ZMY3_MOUSE Unreviewed; 1255 AA.
AC A0A1C7ZMY3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=SH3 and multiple ankyrin repeat domains 2 {ECO:0000313|Ensembl:ENSMUSP00000095542.4};
GN Name=Shank2 {ECO:0000313|Ensembl:ENSMUSP00000095542.4,
GN ECO:0000313|MGI:MGI:2671987};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000095542.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:16452087}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000095542.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000095542.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000095542.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000095542.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR AlphaFoldDB; A0A1C7ZMY3; -.
DR SMR; A0A1C7ZMY3; -.
DR jPOST; A0A1C7ZMY3; -.
DR ProteomicsDB; 367971; -.
DR Antibodypedia; 2161; 337 antibodies from 28 providers.
DR Ensembl; ENSMUST00000097929.4; ENSMUSP00000095542.4; ENSMUSG00000037541.23.
DR AGR; MGI:2671987; -.
DR MGI; MGI:2671987; Shank2.
DR VEuPathDB; HostDB:ENSMUSG00000037541; -.
DR GeneTree; ENSGT00940000153561; -.
DR ChiTaRS; Shank2; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000037541; Expressed in primary visual cortex and 108 other cell types or tissues.
DR ExpressionAtlas; A0A1C7ZMY3; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF17; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:A0A1C7ZMY3,
KW ECO:0007829|PeptideAtlas:A0A1C7ZMY3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 37..131
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1192..1255
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 282..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..312
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..993
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1064..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1255 AA; 134614 MW; 897506C3C0E4F11D CRC64;
MMSVPGGGAA TVMMTGYNNG RYPRNSLYSD CIIEDKTVVL QKKDNEGFGF VLRGAKADTP
IEEFTPTPAF PALQYLESVD EGGVAWQAGL RTGDFLIEVN NENVVKVGHR QVVNMIRQGG
NHLILKVVTV TRNLDPDDTA RKKAPPPPKR APTTALTLRS KSMTAELEEL VDKDKPEEIV
PASKPSRTAE NVAIESRVAT IKQRPTSRCF PAASDVNSVY ERQGIAVMTP TVPGSPKGPF
LGLPRGTMRR QKSIDSRIFL SGITEEERQF LAPPMLKFTR SLSMPDTSED IPPPPQSVPP
SPPPPSPTTY NCPRSPTPRV YGTIKPAFNQ NPVVAKVPPA TRSDTVATMM REKGMFYRRE
LDRFSLDSED VYSRSPAPQA AFRTKRGQMP ENPYSEVGKI ASKAVYVPAK PARRKGVLVK
QSNVEDSPEK TCSIPIPTII VKEPSTSSSG KSSQGSSMEI DPQATEPGQL RPDDSLTVSS
PFAAAIAGAV RDREKRLEAR RNSPAFLSTD LGDEDVGLGP PAPRMQASKF PEEGGFGDED
ETEQPLLPTP GAAPRELENH FLGGGEAGAQ GEAGGPLSST SKAKGPESGP AAPLKSSSPA
GPENYVHPLT GRLLDPSSPL ALALSARDRA MQESQQGHKG EAPKADLNKP LYIDTKMRPS
VESGFPPVTR QNTRGPLRRQ ETENKYETDL GKDRRADDKK NMLINIVDTA QQKSAGLLMV
HTVDVPMAGP PLEEEEDRED GDTKPDHSPS TVPEGVPKTE GALQISAAPE PAVAPGRTIV
AAGSVEEAVI LPFRIPPPPL ASVDLDEDFL FTEPLPPPLE FANSFDIPDD RAASVPALAD
LVKQKKNDTS QPPTLNSSQP ANSTDSKKPA GISNCLPSSF LPPPESFDAV TDSGIEEVDS
RSSSDHHLET TSTISTVSSI STLSSEGGES MDTCTVYADG QAFVVDKPPV PPKPKMKPIV
HKSNALYQDT LPEEDTDGFV IPPPAPPPPP GSAQAGVAKV IQPRTSKLWG DVPEVKSPIL
SGPKANVISE LNSILQQMNR GKSVKPGEGL ELPVGAKSAN LAPRSPEVMS TVSGTRSTTV
TFTVRPGTSQ PITLQSRPPD YESRTSGPRR APSPVVSPTE LSKEILPTPP PPSATAASPS
PTLSDVFSLP SQSPAGDLFG LNPAGRSRSP SPSILQQPIS NKPFTTKPVH LWTKPDVADW
LESLNLGEHK ETFMDNEIDG SHLPNLQKED LIDLGVTRVG HRMNIERALK QLLDR
//
