ID A0A1C9EHI0_9CAUD Unreviewed; 1133 AA.
AC A0A1C9EHI0;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 13-SEP-2023, entry version 28.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=SEA_TONENILI_231 {ECO:0000313|EMBL:AON96951.1};
OS Mycobacterium phage Tonenili.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Ceeclamvirinae; Bixzunavirus; Bixzunavirus tonenili.
OX NCBI_TaxID=1891703 {ECO:0000313|EMBL:AON96951.1, ECO:0000313|Proteomes:UP000204231};
RN [1] {ECO:0000313|EMBL:AON96951.1, ECO:0000313|Proteomes:UP000204231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Acevedo E., Azhar M., Golebiewska U.P., Grzywna D., Guardiola R.,
RA Jackson O., John N., Kanavatsas C., Khan S., Leong J., Mansilla E.,
RA Muladjanov Y., Nouel J., Oh S., Oppedisano M., Sajid A., Samper M.,
RA Ugbeva O., Delesalle V.A., Garlena R.A., Russell D.A., Pope W.H.,
RA Jacobs-Sera D., Hendrix R.W., Hatfull G.F.;
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; KX752698; AON96951.1; -; Genomic_DNA.
DR RefSeq; YP_009288064.1; NC_031080.1.
DR GeneID; 29066629; -.
DR KEGG; vg:29066629; -.
DR Proteomes; UP000204231; Genome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000204231};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..75
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 127332 MW; 14952115F702A1C7 CRC64;
MSSGKAALHN HSETSILDGR SRPEEMAARA KDCGDESVAI TDHDDVGGHF RFQKACQDAG
VKPILGAEQR WMHNIADSRD RKTGGSDSSH IVLLAENNTG LRNLWALSSL AYEPEQFYKK
PQLEPRLLRA HREGLWASDG CMLTRFAEYV VNDQDDLARQ EWAVLLNIFG DHFYSELHTW
QFIDPISPEQ QALNAKMTKI NQAKVRFAKE MGVPLVVVND AHYAYERQWK EHRAIWDMST
GSWKKDQVEE RGHAADWMMN ADEIRHYMGL HGVGASVIEE AMKNSGWIAE QCNAEINGTL
LAMPRLYATD AEDAAAFRRS IEEGFKKFVV DKGLPESVYR ERLEYEAKLI IDKNMAGYFN
VVADYVLAAR NGTYHQAITG DPKPKPCLCG PGRGSAGGSL VTYVMGITSI DPIKYDLMFE
RFINPDRPDF PDIDVDFQKS KKSLVKQYLG KRYGEDNVVS IGTRTHSRPR QMLQDLCRAE
GIPFKEMKQM IDLVEQVDQI APFEEGMELP EDEEPPTWDE VLQEIGGDLA PYAKKYPELF
DKMGKMVNMV RGVGVHPAGV LVNTDPVFPG LIPTRRKGGV DVRATQFDMY EIETLGGVKD
DLLANKGLDV LDIARDLIYE RHGVWIDYDG FGFGVPEDCP PDKVIALNDD KYLSDPAIYE
QIDRGQTAGL FQVNTPAGTK LAMRFKPRSV VDMADLASIN RPGVTRVPGL LDKYIERRHG
RDPVTYDHPL MESITGPSSS MNTYGILVYQ EQLIRTAKEL AGFTPGEAER LRKGIGKKKM
EIINELEPKF LDGCMANPEF VRLGGTRKVA DRIWQSLKAA GAYAFNKSHG VGYALQPCQE
AWVKHYYFDE FITGCLVVHT DKTIRFLREC RQRKRPVLPP DVNQSGAGFT LTDEGIRFGL
TDISGIGDAA MPDILAKRPF KDLDDFLTRA SKGGGAKKGV VDALIKVGAF DFTGEHRQVM
LEKVYRHRRG LSAPVKWAKM TLDEQVAEIA DKRRIKPEDY PIYDFDDPQV IHDLEVEMLG
TFVSHDPMAK YARMIEGVCI RHPMDYDDYE VGAQFVVGGK LVKARTHQQK NGKQMAFLAV
HWNEEDFEIL AFADAWARCR PLLKIGSPVA CQVIKLRGGA ASLSTVERLD TIV
//
