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Entry: A0A1C9WME2_9MICC
LinkDB: A0A1C9WME2_9MICC
Original site: A0A1C9WME2_9MICC 
ID   A0A1C9WME2_9MICC        Unreviewed;       370 AA.
AC   A0A1C9WME2;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   31-JUL-2019, entry version 14.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=ASPU41_02490 {ECO:0000313|EMBL:AOT02386.1};
OS   Arthrobacter sp. U41.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=1849032 {ECO:0000313|EMBL:AOT02386.1, ECO:0000313|Proteomes:UP000095776};
RN   [1] {ECO:0000313|EMBL:AOT02386.1, ECO:0000313|Proteomes:UP000095776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U41 {ECO:0000313|EMBL:AOT02386.1,
RC   ECO:0000313|Proteomes:UP000095776};
RA   Fomenkov A., Akimov V.N., Vasilyeva L.V., Andersen D., Vincze T.,
RA   Roberts R.J.;
RT   "Complete Genome and Methylome Analysis of Psychrotrophic Bacterial
RT   Isolates from Antarctic Lake Untersee.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP015732; AOT02386.1; -; Genomic_DNA.
DR   RefSeq; WP_069949580.1; NZ_CP015732.1.
DR   EnsemblBacteria; AOT02386; AOT02386; ASPU41_02490.
DR   KEGG; aru:ASPU41_02490; -.
DR   KO; K01626; -.
DR   OrthoDB; 853329at2; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000095776; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095776};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       52    355       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
FT   REGION        1     21       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   370 AA;  39012 MW;  95444DA43FE71353 CRC64;
     MSIEAAPESQ QSTSNLRVSE FTPLPSPRDM LAELPLDARL ADVVARGRDE VRAIMDGVDD
     RLLVIVGPCS IHDPQAGLEY ARRLVSQAEK HKEDLLIVMR AYFEKPRTTV GWKGLINDPR
     LDGSHDIAAG LGAARRFLQQ VTALGLPAGT EFLEPISPQY MADLVSWGAI GARTTESQIH
     RQLASGLSMP IGFKNGTDGD LQVALDACSA AAAGQAFLGI DGEGRAALVS TAGNPDTHII
     LRGGRKGPNY SAPEIEATTA KLAAKQLNPR LIVDASHANS GKSHHRQAEV ALEIGSQLEG
     GGTSAGAIAG VMLESFLVGG AQNLDVTEHA AGTDELVYGQ SVTDACMDWD VTASVLAQLA
     ASARIRRTRG
//
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