ID   A0A1C9WT41_9MICC        Unreviewed;       838 AA.
AC   A0A1C9WT41;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=ASPU41_13430 {ECO:0000313|EMBL:AOT04179.1};
OS   Arthrobacter sp. U41.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Arthrobacter.
OX   NCBI_TaxID=1849032 {ECO:0000313|EMBL:AOT04179.1, ECO:0000313|Proteomes:UP000095776};
RN   [1] {ECO:0000313|EMBL:AOT04179.1, ECO:0000313|Proteomes:UP000095776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U41 {ECO:0000313|EMBL:AOT04179.1,
RC   ECO:0000313|Proteomes:UP000095776};
RA   Fomenkov A., Akimov V.N., Vasilyeva L.V., Andersen D., Vincze T.,
RA   Roberts R.J.;
RT   "Complete Genome and Methylome Analysis of Psychrotrophic Bacterial
RT   Isolates from Antarctic Lake Untersee.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; CP015732; AOT04179.1; -; Genomic_DNA.
DR   RefSeq; WP_069951351.1; NZ_CP015732.1.
DR   AlphaFoldDB; A0A1C9WT41; -.
DR   STRING; 1849032.ASPU41_13430; -.
DR   KEGG; aru:ASPU41_13430; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000095776; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:AOT04179.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095776};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          24..477
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          796..838
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          447..476
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   838 AA;  89974 MW;  651AD8CF11CEA98D CRC64;
     MARRQTPSPA GEASQDFVEN IVDIDVTSEM EGSFLEYAYS VIYSRALPDA RDGLKPVQRR
     ILYMMSEMGL RPDRGHVKSA RVVGEVMGKL HPHGDSAIYD AMVRMAQDFS LRLPLIDGHG
     NFGSLDDGPA APRYTEARLA AAALTLTDHL DEDVVDFVPN YDNQLTQPDV LPAAFPNLLV
     NGATGIAVGM ATNMAPHNLV EVIAAARHLI EHPDATLEDI MRFVPGPDLP TGGRIVGLDG
     IRDAYATGRG SFKTRAKVEV EQLSARRTGL VVTELPYMVG PEKVIEKIKD AVNGKKLTGI
     SDIVDLTDRK HGLRLVIELK NGFNPNAVLQ QLYRYSPMED SFGINNVTLV DGQPQTLGLL
     QLLTVYVEHR INVVRRRTAF RLGKKKDRLH LVEGLLIAIV DIDEVIQIIR SSDEVAAART
     RLMSIYDLSE IQANYILELR LRQLTKYSRI ELEKEQEELR REIAELEAIL GSSERLRGLV
     SAELAEIAEK YGTPRRTVLL ESEAVSPTVA ALAAPGAKGK AAPLALEIAD DPCWAILTAS
     GQIARTANQD SLAESGPRTR HDVFTSVVKT SARGEIAAVT SQGRMLRLQV MDMPVLPPTS
     GTPNMAGGVP AKDFITLLKG ETLVGFAPLD DVLAIGTAQG VVKRVQPDYP LNREDWEVIA
     LKDKDTVVGV APAGSDDVDL VFVTRQAQLL RFPASAVRPQ GRTAGGMAGI KLAAGDRVMF
     FGAAGTADSA AVVVTIAGTE GALPGTAPGA AKVTALSEYP AKGRATAGVR AHRFLKGEDT
     LLLAWAGHGP AKASSQAGVA RSLPGEHGRR DGSGIPLSQA IEAIGPSMSW QPDPETAA
//