ID A0A1D1UGI5_RAMVA Unreviewed; 1393 AA.
AC A0A1D1UGI5;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Histone-lysine N-methyltransferase {ECO:0008006|Google:ProtNLM};
GN Name=RvY_01492-1 {ECO:0000313|EMBL:GAU88874.1};
GN Synonyms=RvY_01492.1 {ECO:0000313|EMBL:GAU88874.1};
GN ORFNames=RvY_01492 {ECO:0000313|EMBL:GAU88874.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU88874.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU88874.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU88874.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU88874.1}.
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DR EMBL; BDGG01000001; GAU88874.1; -; Genomic_DNA.
DR STRING; 947166.A0A1D1UGI5; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19172; SET_SETD2; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.10.1740.100; Set2, Rpb1 interacting domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044437; SETD2/Set2_SET.
DR InterPro; IPR042294; SETD2_animal.
DR InterPro; IPR013257; SRI.
DR InterPro; IPR038190; SRI_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR46711; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR PANTHER; PTHR46711:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF08236; SRI; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 402..455
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 457..575
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 582..598
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 1085..1118
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 32..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1253..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1289..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1348..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..189
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1393 AA; 155903 MW; 3A19264991FCF2BF CRC64;
MDRFASFPTP QLFIIPPTGF GMTNGGIVHA DSGEMSGSTT ACSSSSATTS ETKRMGKFKF
LTIPNPSETS LSQPLSSETV SSSSPHHMVE PTSSDAVDET YSPSKLSRRG SATSTDLISN
WHSPAPSDLY SESSQPRPER SSPRKQTTDD DLINKHVERL LKVTDLRDQI PDTEDDYEEE
DDDFESRLDQ MIAEEDQNKK KPRRRAASRG SAVGRRRSTR NSGKSDDKPP SPAKSPAAQP
VSGERTMSQP AEPLSSASSA HRPEKSRRGR KKKVLTDQPI SIPNNGAGPD SLVKDRLLSG
DAASDDAHSQ SSELKDQEDV SDQNRPRKLK NRWAEKATVS APQSTEEPSC QSRSSIDSGK
VLQDITEVET NRPVENMAPT PYEIIPECIR LAKHKQREDR EARKMRCECT FSAEDAKMGM
EGCTEGCLNR MLYIECGPKC AAKDFCSNKR FQRREYPSIE VFNAGSSKGH GIRAKTSVTT
GQFICEYIGE ILDQRQFKKR QKEYDKINLQ HHYSMALNND EVIDATRKGN IMRFTNHSCD
PNAETQKWTV NGQMRIGFFA LRPILAGEEI TIDYQFERYG KKAQRCYCGS VSCRGFIGSV
SDDKRKTAKG EISDRKMVSE IDKFVQSGSI RTDDQALRMA RLLLRVEEDN DRLTLLNVIQ
NSENYHEALR AFLRCQGLTI LAALMFSCQN SRSEIKLELL NTLAMLPILS KNALETSRVL
SKVKEWAGRV VETEGASAAT ATALAQAVVE KADFTPTVTV TEHDELTIKE EKMDVDLWAS
PATSAVPVDS SSSQEVKVKE EENSEPSQKV LSKEEAEEEP SSDRMAPVVT NVDHSTEVKQ
KASELLDSWD SLKMVFKIPR KINFDPEPSS SQSKVSPRPS PSIWGDNGHA IAVLGTPSTW
PARPYQNLLP PGPHDNFYRK RPSYNSNQRR IDLSSKKFMT YLPDKTQSTF PLGKVEEPAP
TGLEDLSAVM DYNVALAEQI RQNNEHAAEM VSQKLLDGSV AVSQKVNIVL RDGSTHDVRT
FQPSEEQVQL IASAIPLIGS KEWTEKYATV LHYTEGRKVN VEPIDAPKIQ NFAGWTSNFD
LSKHLFLPKD WGAAYDRAGR LYFYNTSNGV SRWDFPVEDK EYSTVLQQLP PALAIPADMT
QYSKVHVDTM KITPWSPQGD DELEDKTTPI KRSASTTPKP SKLDPPKMSQ NKEQNRELLK
KKKIDFQNDV CQFVLHFLNS YRAPECPQGR IESKGDFKYL ARKFTHNVVE QEVQRHRNSP
EALSFSSSRH KPKIKEHIKK YMSRFGRTYK GPSTVNNIRG HAKTETPSQN GDHANHDEEM
FETEKTFSQS EMQNGDTSDV HEVEERLSDV KQNGFAKTPD EGRDRPSLAS PLLSSTKLLM
ADTAMEEQSG VVG
//
