ID A0A1D1UHQ2_RAMVA Unreviewed; 482 AA.
AC A0A1D1UHQ2;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE RecName: Full=FZ domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=RvY_01593-1 {ECO:0000313|EMBL:GAU88991.1};
GN Synonyms=RvY_01593.1 {ECO:0000313|EMBL:GAU88991.1};
GN ORFNames=RvY_01593 {ECO:0000313|EMBL:GAU88991.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU88991.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU88991.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU88991.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU88991.1}.
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DR EMBL; BDGG01000001; GAU88991.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1UHQ2; -.
DR STRING; 947166.A0A1D1UHQ2; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF148; SECRETED FRIZZLED-RELATED PROTEIN 1; 1.
DR Pfam; PF01392; Fz; 2.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..482
FT /note="FZ domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008897236"
FT DOMAIN 67..206
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 314..455
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT REGION 205..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 82..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 169..193
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 482 AA; 54364 MW; 1F7F6EDA6A3FF8FE CRC64;
MRPIFLVCLF LPVFCRVDST KHHIEDFDRF DRESNFFSEG SYLQADERNF DFNNAGSAVI
LPVNHPGSQQ KCVDIPQNMS LCHGIGYSRM LLPNLMQHET LREANEQSQT WMPLANIKCH
QHTRLFLCSL FAPICPMQQP QSNTAEDLMQ SDQAFFAAGP VIYPCRSLCE AVKQGCQGVM
SKHGFPWPDM LSCSKFPVDN DMCISPNPSE ERPSTTTTTT TTTMSTTFRR TTTSRPVYLR
TRRPPSVHLT PISFRTMKTT TTTTTTIAEP STTTSTTTTS TTTTTPSTMT AMTSTSTPPT
ATSQLVALDV GETCPVCDFV KPIDQLDEAV CQSAFVAKVR FRRKTRRSVF LAKRPKFLKV
PSARLNHTLD EQMRNARSVD FFFEPNQVSY DCRYFCGQKI ELKNQLYLVL GVFAPSHSRK
STLPQLAIRT ILPWFSGLNS KDFRLAEKSL QQLKCPNHRT SATALSVNHP HTKPRITSRV
HD
//
