ID A0A1D1UHQ7_RAMVA Unreviewed; 903 AA.
AC A0A1D1UHQ7;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=RvY_01825 {ECO:0000313|EMBL:GAU89254.1};
GN Synonyms=RvY_01825.1 {ECO:0000313|EMBL:GAU89254.1};
GN ORFNames=RvY_01825-1 {ECO:0000313|EMBL:GAU89254.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU89254.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU89254.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU89254.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU89254.1}.
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DR EMBL; BDGG01000001; GAU89254.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1UHQ7; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF83; ANOCTAMIN; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 286..307
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 359..378
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 436..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 496..521
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 542..561
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 665..688
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 809..829
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 42..266
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 269..858
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 903 AA; 104048 MW; 85E9F9EA937FBA1E CRC64;
MKSQKRDVEA GDGKAPESLP LNDFKPRKSI KYGFTGDEES LFFRDGRRRI DFVLVYETGT
KTKALEYKRA EKRVNLERAM KKEGIDIETS VQGIPGEGPE AQLCYAKLHA KWDLLIRYAD
IMKLRMPLKK EVEEEAYPED EISRYCPPFF RVDKSVLPPS PHFVSTGFSK SKMALFNILD
RDSFFSPSQR IRIIWECMSR IQFVESNPSG VGIQKLLADD TYLAGFPLHD GPYEAPKGET
KKPTNLRAAL YDQWGQFSKF YKFQPIEHIK NYFGGKMGFY FAWMEFYTIM LIPAVIVGAV
CLLYGMITMK NDIPVQEVCT HPDVKDTIMC PICDRRCPYW RLEDSCMQSK STYLIDNPAT
IFFATFMALW SAVFLILWKR KQTILSWNFD TYYATEQEEQ VRPELEAQIK PDHWKVNPIT
QMKEPYVSPW RRILQAMLSG TVVFFMVLLV LAATFGTIVY RTMVNVAIYA SSQSADAESA
QLNDDEEKFA VKYSTYIVGF TAALLNLIVI LILNSIYYRI AKWLTEKEYL RTQSEYEDSL
TIKYYIFEFV NTYCSVFYVA FFKGRVPPPL PGSRGVFHLP ADRCDKGGCL IELTIQLVVL
FLGSNLVNYV TEMIIPSITR ALRTRKILGP RLRDKREHRW EHDHAAQPYP AMGLFLENSR
MVTQFGFITM FVAAFPLAPA FALISNILEI RLDGYKYLTL YRRPVPTWAK GIGAWGKILE
NVARFSIITN AFIISFSSDF VPKLVYLAAY SMDSTLNGYT KWSLSEFSRL DFPFGTEPVI
PGRDWSPDQL PETCWYREFR TGPARPRPYN LNMTFWHVFA ARVILVLVFE HFVMVMSKII
TFFVPGIPAT LKAKVLRENF LAKETFYEAE TSRLQTPTSP GTKRAQNLPM SPIINLARPE
VYA
//
