ID A0A1D1UJS6_RAMVA Unreviewed; 1030 AA.
AC A0A1D1UJS6;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=RvY_00656 {ECO:0000313|EMBL:GAU87862.1};
GN Synonyms=RvY_00656.1 {ECO:0000313|EMBL:GAU87862.1};
GN ORFNames=RvY_00656-1 {ECO:0000313|EMBL:GAU87862.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU87862.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU87862.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU87862.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU87862.1}.
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DR EMBL; BDGG01000001; GAU87862.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1UJS6; -.
DR STRING; 947166.A0A1D1UJS6; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF494; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 550..840
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 911..1030
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1030 AA; 117970 MW; 86FB491D9E693D90 CRC64;
MSAMQKPEKF EIFGCFSAIF FSILSAEVND VEHRKKPPPI MNLTLFAVFP TNGDLFYRQQ
LTRPTLDYAL EELRNTTLSG YHIRLDFEYI GTSDLNDCGR VNNVVVYKTI EQVTVLSLTA
AFTGTPAIVP AAYFGPGCLK GVEDMATWLV TQQQPLFDAV ASSDTLRDKT QFPTIIRTGF
TDRRLKDFHR KMLRHFQWNN TQVQYLAARD DPVWRGIASL HPRPIRICGT NTSDLGYYQE
TLSAVLLRYT GVVFFAPMDC VKTILIEAVK MNLTSPAGQL TFIVTNFFDT RYWGTMRLNA
SQYNSAVGTT VEERMYLQEA YKQTFLMTYY MPETAEQHMR DLNDKVLEYV RNNKHEFSDE
FFYEQTLVEE GINPSVMGYY ASVHVFGQAV KEYFDRYGRP ADADQVPPFW KQRILEIIRR
KKTFRIPNLG TIVLNDEGDT EGSFALRAYN SSTDTFETWM YYLEGDTDLK FAMDEDYYQP
ACSPLTTPAP IFTTTHKTTV WTNTPAFVFG LITCSIVGAI VASVAISYYV KKAQLGSKWW
IINPDELKPI PDQKAMLEGK RMSLPKSFDG LSTASGITWY QEDQKSEHRY CKDVALVHYN
SQVVATRKLT YSWKLSCNML SELRDVRLHN HVNLLKILGY VVENNDCKVV NEHAPRGTLA
DLLTLGELEW SFRYSLLSDL IEGLMYIHKF FHSHRRLSSL NCMIDRTFVL KIRDYAPKCL
QPALDNMCPW EKLWTAPELL RGAVEPDYQR ADVYSIGIII QEITASSPPY PSDDRQTVKY
DPEDIIWRVK RGGPVPFRPI LPDGVNTCDG LRGVMEKCWS ELPEDRPLLP YLKNKLRGWR
GTVKRNLFDN LMDRIQAYAG QLEHEVEVRT QQLREEQHKM QSLLYELLPK SVADRLIAKN
PVDPEPYDCV TVYFSDIVSF TTISAESSPQ QVVQMLNELY KLFDGIIENF DAYKVETIGD
AYMVVSGLPN RNGNAHARVI SLLALNILQA SGHFRIPHRP NEHFKIRIGL HSGPCVAGVV
GKPRYSYSLV
//
