ID A0A1D1UKB0_RAMVA Unreviewed; 927 AA.
AC A0A1D1UKB0;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Amino acid permease/ SLC12A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=RvY_02603-1 {ECO:0000313|EMBL:GAU90139.1};
GN Synonyms=RvY_02603.1 {ECO:0000313|EMBL:GAU90139.1};
GN ORFNames=RvY_02603 {ECO:0000313|EMBL:GAU90139.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU90139.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU90139.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU90139.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU90139.1}.
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DR EMBL; BDGG01000001; GAU90139.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1UKB0; -.
DR STRING; 947166.A0A1D1UKB0; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF72; GH08340P; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..580
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 591..676
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 771..918
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 927 AA; 102214 MW; 11D582D5819E358F CRC64;
MDRFQLFSQS IPSLSDIMLS PTGSSSEIRS INSSTDRPLQ QQRSLFRSLA GFGRNRQSSI
NADDVEYEEF PQSSHRRLST FSGVFAPVCL SMFSAILFLR LGFAVGYAGF LLTLGLFAIA
YVIVTCTVFS VCAISTNGAV ESGGAYYMIS RALGPEFGGA IGLLFFFANI CSGALYVSGA
VETLINSFGP GGSLSDGGLL DGRWYSFVYG AVICVFNMGV CVVGASMFAY MSAFILAVVA
TAAFISFLSF FINSSELCID IPRTNQFYYG SNATDNITYC EKYTGLSKAT FANNTYPHFD
LPDYTSGMEV DTATVFAVLF NGVTGIMSGA NVAGELKNPA KAIPRGTLSG LATTAVVYTT
IVVLTAFSCT NDLLRNNYTF MQAISVWAPS VDIGVLAATL SAAMTNLMGA SRVLLAVSRD
KLFGSLLSPF AKTTSSGNPI PAVLLSFLLT VIVLLIPSLN QIARITSIFF LLSYFGNNLA
CLAMELASAP NWRPKYNFFS WHTAFLGMCG CGVMMFIISP IYAAVSFAVA LLLMLSLHFW
SPDINWGSIS QALIFHQVRK YLLLLDIRKE HVKFWRPQVL LLVSRRDTAD NLVDFINDLK
KGGLYMIGHV KKGSFEDLEV DPLQEEYSEW LEYVDRLRVK AFVELTMART VREGLHHLVH
LSGLGGMKPN TIILGFPRYC NPTIPSSEFV SSPFSIPHQP PGLSSREFVQ ILRDCLRMRK
NVCIARNFQT FDKRGTLQSG PVQIDVWPVD LMRPSLVDNY DTSALFLMQL ATVLQMTSTW
RRRSTLRVFL THRQQTDNVL KRVRTLNNLL GQLRIQGKVV PVVWDDAMQH IDRSTTASYV
DSSLSNEVSS PVSEMQPYSL PEGYVHAVQR LLRFHSQTSA LTFLYMPRPP SDVTKSEVYM
DFLESISSLP SPALLVHGIS IVTSTTI
//
