ID A0A1D1UTZ1_RAMVA Unreviewed; 591 AA.
AC A0A1D1UTZ1;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=type I protein arginine methyltransferase {ECO:0000256|ARBA:ARBA00011925};
DE EC=2.1.1.319 {ECO:0000256|ARBA:ARBA00011925};
GN Name=RvY_05120-1 {ECO:0000313|EMBL:GAU93134.1};
GN Synonyms=RvY_05120.1 {ECO:0000313|EMBL:GAU93134.1};
GN ORFNames=RvY_05120 {ECO:0000313|EMBL:GAU93134.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU93134.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU93134.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU93134.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) +
CC N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319;
CC Evidence={ECO:0000256|ARBA:ARBA00001817};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU93134.1}.
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DR EMBL; BDGG01000002; GAU93134.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1UTZ1; -.
DR STRING; 947166.A0A1D1UTZ1; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006:SF10; HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED; 1.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR Pfam; PF06325; PrmA; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01015};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01015}.
SQ SEQUENCE 591 AA; 65735 MW; 65BFF10DE47155EF CRC64;
MAPSIPMQSP VLCQVAGVTL YRMDGLTFTE YVPTCTIVLQ KKSDANSGSS FVLRFMNDSE
DLGSIAISQT TESATIKDKT LVFSPPDASG ETMAVSFPNE EGFSQFKEML SNIRNGKVQS
LFEKRTEETS AVQYFQFYSF LSQQQNMLQD YVRTSTYQRA IQLNDVDFRG KVVLDVGAGS
GILSFFACQV GASRVYAVEA SSMAEHCNLL VRENKMDGVV KVVHGKVEEI TLPEKVDVII
SEPMGYMLLN ERMLESYIHA RKFLKPGGRM FPTIGDLHIA PFTDEALYME QLSKANFWYQ
NAFHGIDLSG LREKAFDEYF RQPIVDTFDI RICPSASVKW SINFEQDKES DLYNIDIPLS
FPLVTTGMIH GLAFWFDAGF LGSNATVWLT TAPNQPLTHW YQVRCLLKTP LFGVKGQILS
GRVLMVANGR QSYDVTIHLG VEGSGSKSSN TLDLKNPYFR YNGAPVEPPP GTSNHSPSDV
YNAQMQQQYQ LCQSTASMQV GQNYNGTAVN GQMMYQNYPQ MQQQPYMAAV PEPVPAFHNS
QAQLPQVRYA TNSGPAQQTV GSPGYGAPPA TVHQSAAIPR YSTNYQYAPH N
//
