ID   A0A1D1UWF7_RAMVA        Unreviewed;       740 AA.
AC   A0A1D1UWF7;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:GAU92785.1};
GN   Name=RvY_04823 {ECO:0000313|EMBL:GAU92785.1};
GN   Synonyms=RvY_04823.2 {ECO:0000313|EMBL:GAU92785.1};
GN   ORFNames=RvY_04823-2 {ECO:0000313|EMBL:GAU92785.1};
OS   Ramazzottius varieornatus (Water bear) (Tardigrade).
OC   Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC   Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX   NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU92785.1, ECO:0000313|Proteomes:UP000186922};
RN   [1] {ECO:0000313|EMBL:GAU92785.1, ECO:0000313|Proteomes:UP000186922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU92785.1,
RC   ECO:0000313|Proteomes:UP000186922};
RX   PubMed=27649274; DOI=10.1038/ncomms12808;
RA   Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA   Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA   Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA   Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA   Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT   "Extremotolerant tardigrade genome and improved radiotolerance of human
RT   cultured cells by tardigrade-unique protein.";
RL   Nat. Commun. 7:12808-12808(2016).
CC   -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC       microtubules are slightly longer, but more dynamic.
CC       {ECO:0000256|ARBA:ARBA00003210}.
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC       {ECO:0000256|ARBA:ARBA00006489}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAU92785.1}.
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DR   EMBL; BDGG01000002; GAU92785.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1D1UWF7; -.
DR   STRING; 947166.A0A1D1UWF7; -.
DR   Proteomes; UP000186922; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13720:SF58; HELP DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF03451; HELP; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          94..132
FT                   /note="HELP"
FT                   /evidence="ECO:0000259|Pfam:PF03451"
FT   DOMAIN          510..596
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
FT   REPEAT          535..576
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  80989 MW;  CD10FF8F11F9A788 CRC64;
     MKGLFGRKKG NAKETDSPGQ SLTLDNSSDS VSMASANYGT IAKGVALTNN GMTGANGLQE
     KAIRPVVRKI GDHKIILWPP DEYFDTVTPK VREPSLEWVY GYSGFSHRNN IVLLHDTAII
     VYFVGRIIVL YNLNADTQRH YCEHDGIVQC ISVMSNGTIA ASGQQPALED GPAIVRVWTV
     DHLQTLHVFK SDASMGSALR KSVAALSFTK EEDAIVAIDD GKPRTMSVWS LETGQMLASK
     PCTESPVVCG ILCLRASSKD PLYLVYGRNL MEIWKIVPTE NKIDFVKQCV FGQIPKPSIV
     TSVIEAPVVV DGMPRTVLIS GDSDGNVILW SDEMRPKNVL QNGNKVPVFT LCSLSPSHVM
     IGSRDGQMGV IRLAGESTVK ISKNKIPEQY GGLRMLTPMK DSNSDTGLDV SLSVIAGTTA
     NALLRVTFTT TNGEPEADQH DMQAVTVGHF DEAVGLSTYV HPEDNTRTMA ITVGMDGNIN
     CFDLAKHAPA WRTFLKDSMV TAVDCYPPFL VVGTSDAKLK LFHLTEPELT LILQASVGKE
     KVACLKFSPD GTFFAVASQD GEVHIFRLEE TEGVSASFVS KFDKHDYPVI AIDWSRNPAR
     DGHYVIHSNS YEFENLLWDA LTTEFLEEAH FYRNVKWLTQ NCPFGFASAT SVTWDNNSLE
     GNVVCTDVSP TLDMVAAVVT GQRNQIGLYS YPNANVAVVK RMQPTCSTTI TSLKLCYLNN
     TLYLLCTHGG DGSVSQWALR
//