ID A0A1D1UYC0_RAMVA Unreviewed; 307 AA.
AC A0A1D1UYC0;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN Name=RvY_05328 {ECO:0000313|EMBL:GAU93375.1};
GN Synonyms=RvY_05328.2 {ECO:0000313|EMBL:GAU93375.1};
GN ORFNames=RvY_05328-2 {ECO:0000313|EMBL:GAU93375.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU93375.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU93375.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU93375.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU93375.1}.
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DR EMBL; BDGG01000002; GAU93375.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1UYC0; -.
DR STRING; 947166.A0A1D1UYC0; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR CDD; cd00064; FU; 1.
DR InterPro; IPR021852; DUF3456.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24038:SF13; PROTEIN DISULFIDE-ISOMERASE; 1.
DR PANTHER; PTHR24038; STABILIN; 1.
DR Pfam; PF11938; DUF3456; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00261; FU; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..307
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008897788"
FT DOMAIN 146..188
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 284..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 178..187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 307 AA; 33706 MW; ECEC6B6A613472A4 CRC64;
MLPRMFGWIS PCSTHLYLAT AVCLSAIASV YSADLKVQCQ ACKDFVQTFW QGHENTAKSN
FGGGNTDWEE TRLGSYATSE TRLVEIMEHS CTSGTDKDQC HQFVEHNEEP IEKWYFHLQK
AFPNFEKWLC MDNTRVCCPP NTFGPDCEPC PGGTENPCTG RGTCEGSGTR EGSGACRCQK
GYSGAMCDLC DSGYEITDRN DTSITCEDID ECELDPLTCK IASEYCFNTE GSHKCYKCHP
ACHGGCSGAG AGRCKNCADG YIQVNGTCID EQVALKEQDQ ALSDNKVPVE ASLSDHQSLP
NDERTDL
//
