ID A0A1D1UZA8_RAMVA Unreviewed; 857 AA.
AC A0A1D1UZA8;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 22-FEB-2023, entry version 17.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=RvY_06641-1 {ECO:0000313|EMBL:GAU94944.1};
GN Synonyms=RvY_06641.1 {ECO:0000313|EMBL:GAU94944.1};
GN ORFNames=RvY_06641 {ECO:0000313|EMBL:GAU94944.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU94944.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU94944.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU94944.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU94944.1}.
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DR EMBL; BDGG01000003; GAU94944.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1UZA8; -.
DR STRING; 947166.A0A1D1UZA8; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 406..430
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 451..469
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 558..577
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 589..609
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 664..683
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 787..811
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 702..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 94..121
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 702..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 97395 MW; FB154153C167FE8B CRC64;
MGTLFRSQEM ALCQFFLQSE AAYCCTAELG EIGAAQFRDL NKDINAFQRK FVNEIRRCDD
MERILRFLEK ECQKEKVPVL RLGENPMAPM PRELVDLEST LEKLEREIKE VNVNFEALKR
SNLELLEMKY VLKKAQQTFE LDGMAVLNPE SKSDTELLGT GHDATQVHRG VHISFLAGTI
PLIKVEAFER LIWRISRGTV LLRTSNIEFP LEDPATGDEI LKATFFAFFQ GDTLRVKIRK
VCEAFRATIY PVPDSPAEIR EMSIQVMTRL EDLKTLIGHT QQHRHMVLLA SAKNLDLWEI
KVQKIEAVYA LMNCFNIDTT QRCFIGEAWV PHQDMEAIRL GLLRGSEKAE CSVPSFITPI
KTAETPPTYH KTNKFTSGFQ AIVDAYGVST YREVNPAPFT VITFPFLFAV MFGDAGHGFI
MACLAGLLLW KEKAIMAKRD KGEIATTIFG GRYIIFLMGL FSIYTGLIYN DIFSKSFNIF
GSRWYPRTSI YNLTMEADKL AGATFQLDPT PNALLGSDYR YEGRYSIGGP YPFGLDPAWA
MSSNKINFIN SYKMKMSVIF GVFHMAFGIV LSCFNHTYFK RRVNIICEFI PQMIFLMCMF
GYLVILIFYK WTKFDASTSG CSPSLLIGLI NMFLMKNEPN PKNQDGTECH MFKFYNSQES
LEKALVVVAV LCFPWMLLSK PLYQRWRQGR VAYSTVRAAG SDTESVESGQ SRSPTSVPDE
GGHGDGHNEG FADVMIYQGI HTIEFCLGII SNTASYLRLW ALSLAHSQLS EVLWNMALRK
GFMMNNIGGA IVLFTIFAWW ACATFGILIC MEGMSAFLHA LRLHWVEFQN KFYQGTGHAF
EPFDFKKTHS TARLDQD
//
