ID A0A1D1V0Q6_RAMVA Unreviewed; 1008 AA.
AC A0A1D1V0Q6;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Retinoblastoma-associated protein A-box domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=RvY_07053 {ECO:0000313|EMBL:GAU95434.1};
GN Synonyms=RvY_07053.1 {ECO:0000313|EMBL:GAU95434.1};
GN ORFNames=RvY_07053-1 {ECO:0000313|EMBL:GAU95434.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU95434.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU95434.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU95434.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU95434.1}.
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DR EMBL; BDGG01000003; GAU95434.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1V0Q6; -.
DR STRING; 947166.A0A1D1V0Q6; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20548; CYCLIN_RB-like; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF36; RE32990P-RELATED; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 67..216
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 411..606
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT REGION 645..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..970
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 112254 MW; 95DB2BE570C59711 CRC64;
MAPQRRESTP DTPTSELRSR YLSVTKDANI DTKTAQHAMT MFETLQEKFN VEGDPVEWLL
PGAYAYSISQ KPSNVESKVV LWKLFKATSI SVPVFFQRVK KWGEVAGLPG AARELFSRSE
RYFLMSKTIF GSFEQMYTCV FRDPLDADLL KNVTDRAMSL RKKQKVVFPK IVQSVDVYVF
TWDLFVRCRL SAQALRDDLI SCYHLLICVL DYVCANVLAL KRDELLNPGC SIIPKVAEAD
EKTISTFSLI PYLCAKFEGI SRDCQILYSN GFLPLLHQLI KDQELTTDGL GVTTGLLSPE
NFEKNVKSLN SIYENLVRIT MAGDERVFLV SGDVNNPGVG GDPLNVMDVI ETMKGRRKML
PSINRKLELN DFKTPTPVVS GLSISTSSTP LTPNSSCSVL ERREQQESAK TPALLTAVDL
VTQLTNLTAG RTTKPSTLLA ELLKSVYEED VSASFTKRAA DYVEKLVKAY TEADDPKGLA
EPYIRARFMF AQTWYFKILE DVLVSEKQRS AGTFTRMKRL IDAERFQKSM LALAVEMILY
SYNCSRMFPW PIEALEVSPF DFVKVIEPVV RLEPLPRSIT KHLARIEETI FEQLVWRSES
PVWNEIAAEE TRSVREVCWA HNLEETPTTG PRLPTTVSVE APAMFASPST PSSSRRIKKE
PASPGAAAMP APSSAAAPAV TGGGVPTGAV RPPKSSAICL FFRKVYVLAA ARLRDLCDKL
GFDAQIEAKY HVFQRMFTLF EEVLSKHTPI LKDRHLDQIL LCCAYVIAKL ETSNGLGKTF
HTIMNAYRYQ NQAESTVYRS VLLLKKAVAP SPPVPTSIIE TRRRAAQNIA DQNADPITQG
EVRTDIIRFY NEVFVDVMKD FIANLTPKKK GPSTVVLSPV PSVSGNIVRR QVHPGAPIYV
SPMRKEEPQE PLPNGRVLQF TFGVSDDMSK LVFPDQKPTP KPRKKRENPG GSVTPRKYKR
GTKDSARKAK SSPGKSAVAG PANASLTVPI PFVPPKDAIK SEPETSAS
//
