ID A0A1D1V185_RAMVA Unreviewed; 1069 AA.
AC A0A1D1V185;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
GN Name=RvY_07115-1 {ECO:0000313|EMBL:GAU95511.1};
GN Synonyms=RvY_07115.1 {ECO:0000313|EMBL:GAU95511.1};
GN ORFNames=RvY_07115 {ECO:0000313|EMBL:GAU95511.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU95511.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU95511.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU95511.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU95511.1}.
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DR EMBL; BDGG01000003; GAU95511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1V185; -.
DR STRING; 947166.A0A1D1V185; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR CDD; cd00173; SH2; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 142..247
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 116407 MW; C3C15E76DEF46B18 CRC64;
MLSDVSSGIR RYSLASSSSA ATSESVNTTS PSSRSASSWI TPLPHHHGYQ REITSESVPG
NPEDSQQQGG NGKESNKMKV DTVGRQNMYL KGVEGVVEGA AVSVAGLENG RSSTAFAAAV
NTPFIDDKIT MLEKVAGTQG IWFLAGLDRQ TAEVYLKPAG LGVFIIRPSS LAGTLALSVN
IPSSQHFMEF DQHKSHPCQR VEHYLIEHKS GKLSLEGSAV HFPSLPALVE YYSHNRDELP
VPLCLPSTLD QIQTREQLQM VGKVAKPADF WMTIGAVVNI ETGQSALRSP SMLLESLPLN
EERQTTTTTA KLQLPHGSAF ERRVRHSRAS PDSTSGNISD IENKPAGEAK IGAQSRLSSK
VSDYEDLWSL TDTKSADFTM SSISQNGSTP DHSRSLEYHD TASKTSKAVV GVALRDLDAL
GEWIESELHD SQVSPKGTTA SVSTPTTPDI TINESSTNHP DLLNENTRVI RRGKRRFANN
AAVSRNRFSA PNLSVNVEDV DSSESTDGSS DVRNTHHGVE PVSVYEHDDD CVPEEFPCYT
PPPRKCLPSR DQNILESFQS KVGALKRIGS KLLSRKTSLK NVNTSGSLTK DMPAQLHERV
LVFRAKKPSY DTCWPVDNDN WSVMNRATPT SDVTSSGTSS STGSAGARSA GNPQNGRYLT
VRSSKSPAGS LPKRSKTISD FSLDPSHNLE RDISIERAVT FVIKCTKADF ALSLQIGDFL
QRFAATPTED LITLCSDLRL FVVAIRTYIL LEHGPSLEDF LSRDCPADSE VKRPQSLELY
VDSAVQRLIV DPLCPKIIWT IQNNLGASGQ FISLEKGCQV LDHTEATVEN LPTEIQSAVM
DKLPALSAHF KNLADSHNLL SKTKQLLMIF WDIFGVDADP LEYSFADTTA AFAFAIARTK
AYNTEVHLDF IWQLQPTDLK YANYFPVLLA ASCATTVLKS LTNDSKPSLS EATARTLVSV
IVSIKSNDTI PSIGHNVQVP MDRRLNGSQL ILLLAEICDL SPDTSDMTLE LSAGCLGIAQ
TGEIMVRPSL DRWRSVFPNS RLMLHVRTKT RSSASPSATD GVVPASTDA
//
