ID A0A1D1V3A8_RAMVA Unreviewed; 1166 AA.
AC A0A1D1V3A8;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=MAM domain-containing protein {ECO:0000259|PROSITE:PS50060};
GN Name=RvY_07007-1 {ECO:0000313|EMBL:GAU95380.1};
GN Synonyms=RvY_07007.1 {ECO:0000313|EMBL:GAU95380.1};
GN ORFNames=RvY_07007 {ECO:0000313|EMBL:GAU95380.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU95380.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU95380.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU95380.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU95380.1}.
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DR EMBL; BDGG01000003; GAU95380.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1V3A8; -.
DR STRING; 947166.A0A1D1V3A8; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR CDD; cd06263; MAM; 2.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF142; MAM AND LDL-RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00629; MAM; 5.
DR SMART; SM00192; LDLa; 2.
DR SMART; SM00137; MAM; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50060; MAM_2; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1166
FT /note="MAM domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008897970"
FT TRANSMEM 1104..1132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..220
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 223..414
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 410..584
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 607..825
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 867..1034
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT REGION 1055..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1166 AA; 128652 MW; 2CADC08673BB1184 CRC64;
MVLRSHFFAS LLLGLLFCGS DESAAHDETT PGSTTKMPKC PSVPFNCTFS DKATPLCVFT
SLSEDSACKW RQNEGPSPNF PNTGPPSGHI SKDTADGYLL FESNKCTKTE TTATITTKID
NAQIEKPSQC LKFYYFMYGG PNSLDVTVKF KTGVERKEFH REGNQGRRWF PAYVTIDNPQ
NETYKLSFTA KARDNIVHSE TNLGDIAIDD IDFSDGGCKA TKDLCDFESG NLCGFTSDTS
ATGANVAWTL TKAGNLSASF GKIKTDHTFQ TSEGHVASCE IKGDEVARLV SELVNTTETK
NYHITFWYQI VSLGQMSLRV NYITGDSLPA PIQWDETIPI WSINNTFSPY AGWNFASVIV
LAAGEGRADK LVYAFEASES VREGGREQVY SFVLDDITVV ISDDDPYNPP NCDFENGECG
WTAAGPNNNI GNNWVNFKAE YNLGEYGPYA DHTRNSSKGH FMMFSSDYES NPGAVQKGSL
WSPKVSRPRS ATVCFSFWHY TYKDRGANMD LSLTLHEPAL GASAGNRTLI QLTDPPQNRW
TFVNVSFEAR GDYQVVFDSS FFNASRGNVI ALDDFQDKEG ACDVHSGTFK CTNGDAIPYA
EVCNGRYDCR KSGSNDDTSD ELMCGNFTSL SANHTDAVLN ITSATGYFIT SPTNFKWVYT
PHCDTSDTTE DCRYPTSGHN DTFNLGYFKA DFADSPNATS TYTYLHSPTI HRLFSTTSLS
FWYNIYTPRP ENHSDTGALI VSLQMISTKT SIALVDVTAI NDSDQPLSHW QHHNVTVGRI
EGEFHFLFQA RKARIHQGFI AIDEILIEDR MLPVPDPADE IACKNKTLWH CDVTRICIEQ
DKRCDFTDDC GEREDESETD CQKTHPFRCS FDDESLCGFW KNDHPKSDVR WIHTASRTPT
AYSGPLRDHT TGLKGGGYIH APSVNGSVLE RHKAVLYSPV FASTEENGHC WMRFYYHMFG
EHMGSLEVIT GIESSPNFSS PLFNARGNHG DHWLRGSVNL VSSAPFRVAF IATVGGVRSD
LALDDISFSP KCRLYDTSTV PTLLPVTSTS RPIDLSSARP GTTIQPTSTN PATGYTVTDS
VKSTVSSDTT SSNPATPPVE QVPYGLGGGA IAGIVIGLLI VLAGGFVLLV LYSRKGTSGS
IMPRGVWSRD RSTNYEEFTD TENLEL
//
