ID A0A1D1V9U8_RAMVA Unreviewed; 939 AA.
AC A0A1D1V9U8;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=RvY_08220-1 {ECO:0000313|EMBL:GAU96842.1};
GN Synonyms=RvY_08220.1 {ECO:0000313|EMBL:GAU96842.1};
GN ORFNames=RvY_08220 {ECO:0000313|EMBL:GAU96842.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU96842.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU96842.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU96842.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU96842.1}.
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DR EMBL; BDGG01000003; GAU96842.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1V9U8; -.
DR STRING; 947166.A0A1D1V9U8; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06352; PBP1_NPR_GC-like; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF494; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 399..676
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 746..876
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 687..714
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 939 AA; 106490 MW; 1ED17DC8F43E2A4E CRC64;
MLRFLPYQQN DLVQTMTLFL TRHKWLDIVL LCDVNPSLGN FFTVACQGFQ DGILQMPGTN
LMSYNFDTRS PTDYGHYLTL GSLRSRIFVI VAHGNITRDI MIQAHKLKMT NGDYVYITTY
PLEHPLYGFY KWRFEDENDD AAREAFLSLY FVSTRPLRGP DYRSFEVELK YRAYKDYQFM
YAADERVSAF TALQHTVVTF TGDIINETLA ETGVINDGKT IMQKAFALRN VSSVTGDFMI
NNGDRVQYIY VIVGMQHHTY TFREYFEYDT TVRKLARTPG QRLEWAYRQD APPNTPFCGF
DGSDVRCSNA LSITVGIICG LIAAALILGL TVFCVAKHTK SDVELDDPRW SIPRDEINFL
NLQSNMSASQ TASRNIGSTV AKSQYSLRTG LNSQVSGSRV TKGTRGSGMT NSVTKDAHVA
KWKNKLVWVH EIKLSHKFSP SGAQEDLIRK MKRINGPNLA HFYGFSPHDG VEMGVLCEIV
ARGSMTDLMA SDKVKFDMAL KNSVIRDLTN GLMYLHDSLV GHHGDVNCGN CLLDNRFVLK
LAYYRLDFLP RATPSSLDED NEYRQFLCFA PEQLRAPITH IFRGSKEADV YSYGHTLYNL
AAEVEPFEEE MTQHNFTPKV IVDKVITQSI IAFRPRIPNG MDRTLRTIIE QCWDDKPLNR
PTMKAVDRLL NTIPGFQRDT NFVDSLLQRM SQYAEELENR IAAATAGMIE EKKKSEELLF
QVLPRHLALA LTQGRKIEPE SFSAVTIGFT AIANFGDIAL QSTPMQIVDL LNDLYSMFDA
TLELFNVYKV ETISDSYMIA SGLPERNGDE HSRQIAKVSL ELMAESDNFK IRHRPNERLQ
LKIGFHTGAC AAGIVGSKMP RYCLFGDTIN TASRMTSFGK ALKIHVSTSA KEHLDRFKEF
RFSFRGLVEI KGKGQQPCYW LLQKHEQDDG QVHAPQSLA
//
