ID A0A1D1VCI9_RAMVA Unreviewed; 888 AA.
AC A0A1D1VCI9;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 22-FEB-2023, entry version 17.
DE RecName: Full=GPI inositol-deacylase {ECO:0000256|RuleBase:RU365011};
DE EC=3.1.-.- {ECO:0000256|RuleBase:RU365011};
GN Name=RvY_07686 {ECO:0000313|EMBL:GAU96208.1};
GN Synonyms=RvY_07686.1 {ECO:0000313|EMBL:GAU96208.1};
GN ORFNames=RvY_07686-1 {ECO:0000313|EMBL:GAU96208.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU96208.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU96208.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU96208.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- FUNCTION: Involved in inositol deacylation of GPI-anchored proteins
CC which plays important roles in the quality control and ER-associated
CC degradation of GPI-anchored proteins. {ECO:0000256|RuleBase:RU365011}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the GPI inositol-deacylase family.
CC {ECO:0000256|ARBA:ARBA00006931, ECO:0000256|RuleBase:RU365011}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU96208.1}.
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DR EMBL; BDGG01000003; GAU96208.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1VCI9; -.
DR STRING; 947166.A0A1D1VCI9; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR012908; PGAP1-like.
DR InterPro; IPR039529; PGAP1/BST1.
DR PANTHER; PTHR15495:SF7; GPI INOSITOL-DEACYLASE; 1.
DR PANTHER; PTHR15495; NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED; 1.
DR Pfam; PF07819; PGAP1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU365011};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365011};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365011};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365011};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365011};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365011};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365011}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 586..605
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 617..633
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 645..665
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 672..692
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 712..744
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 765..786
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 841..859
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
SQ SEQUENCE 888 AA; 100112 MW; DC0F2E0D483FAEEF CRC64;
MDIPKRFVAV VIVLGLFAVG ILDVLFNYEQ NLCQMTYMFE QPDYTRIPLN ESVVENFPSY
GLYVYGEGQR ATQYKRNIFN GIPVLFIPGN AGSFRQGRSI GSVLLRMAEK KRHSKVHFDV
FTIDFDEEFS GLYGGFLQAQ THFVLQCLDK IGAMYKRKVP PKVVLIGHSL GGMIARGLFL
NPSFDTASVS TIFTLSTPHR PIIVADFDYG EYFDDVNDYW TRSVNGSLRH VVMVSFAGGH
RDVLVRSDRS DLTLLFGDND RFISITTTSI PAVWASTDHL CIVWCKQLVI ATARAIFDMV
DFEKNSIIDN VQQRKAIVQK HFLNTLERTR HGDAQNFDFK ERSVRDHKAD TKTSSLDIRT
KKFDEPFYQL YTFPENLSHD IFITWNRWMG REFIHVCDVS DCSRARTLTV KPVALPLTSE
DSSFYTLIPQ SELQLDFALL FEVPKRDEAI ELYASLTLPW TNVTRITFVD ALMGSLGRGS
VFVLSGQKYA RFNISLHEVW KAIDVRVASD EKCSGVMKFS VPGFAQDTYK RLDSKQSRTV
FPLKLQSAVK DGEQSLLELF LEPGCSYEVS IGVDWTGILG QLIRFYVMHL PAYFAAVVIL
RLLPLSLHRK VRLVDHVIVN AGAICVVIAS RFIPELKGFD VGFEGASVVS AVELWIVFYV
IAWSIVQALE TLLRVAVIAY SYPVHFVAKL SVRRVNSLYS RLPGWASRRL MVIPVLSVLG
FVVASATCGE NGMIFAVVLY FLRVCHARRN SQMTSEGAST DVEDYSTMLL LALLVTMVNI
VPALVWTKKL PSALLSQWRS VFTGLDPDPS FMVSVLVGVV LDLTSRSRVK KAVLSRASEV
MDLLMSFLIF TAAALILVFA QKTFYLINVF LGPFLTALSC DRFLKTFM
//
