ID A0A1D1VD32_RAMVA Unreviewed; 1456 AA.
AC A0A1D1VD32;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=RvY_09192-1 {ECO:0000313|EMBL:GAU97982.1};
GN Synonyms=RvY_09192.1 {ECO:0000313|EMBL:GAU97982.1};
GN ORFNames=RvY_09192 {ECO:0000313|EMBL:GAU97982.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU97982.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU97982.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU97982.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU97982.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BDGG01000004; GAU97982.1; -; Genomic_DNA.
DR STRING; 947166.A0A1D1VD32; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 6.
DR CDD; cd14548; R3-PTPc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1456
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008898280"
FT TRANSMEM 1079..1103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..196
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 197..288
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 463..554
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 736..820
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 821..917
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1160..1420
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1337..1411
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1456 AA; 162110 MW; 05206FE34B4F7017 CRC64;
MKFNMSLLNV WTFLVPLITL PQNSRSAVLT VNFPNSVLPP PSSADIYTFL FAHPDGSPPT
ELKYVSENYS TPLIVSNVVP SSIYNVTVLV NDFPLPTKQF LSSPDPPVNL KADVSSPNET
VVYWDKPEGK VDNYRMKLLS RDAQGKISPG VPMDWKEQQI RITPLLPGGE YAMEIVSVFQ
GLASTATRIP FMQFPAPPKN FRKLAMLTNE TSLVLQWDPA EGFVDTYYLL IDAPVQPNES
LAPPFTLRHV FQKLKPGQTY QVAITSVRGN FSSVPSVINA TTRPLPPAEA QQVFSSNDPR
TIEISWLPPA SGHADGYRVS LNASDGSSFN TTRNDATWTG LVPGVQYTVN IESYVVGPEG
LVLGRALKKT VSTRKVPDDP TVSLVAVPTA AELTLEALDN SVRFLEANAT SEDNLVTKGD
VSDGRHVYFR DLVGGTHYLI YAKLLRNDVP MVVPFENMTY PLRPVNVSAS TSSITSIVVQ
WSRPLNTRLQ GYEIVYSKHD DVAVNNVTLP DSGVNYYNLT GLTPGTKYSI QMRSLIENVR
SADSETVSQC TRPLEPLSVT IKPLSVKLLL QLTRPSNSTK YYRVRLVNLD LKDLPPRSMD
IRNDSSIVQV PIPIDYLGAV YEVRVSTFMC DLTSDPVTVV VSSLPPVVNF NRPPAEVTQK
SIKLVIQPSW PPARSILDRY AFQISGSLPR YYLPSELKSQ TVEFDNLVQG TRYVISAWTE
RGEVSSDKKS IEVQLKPDNV TNLNISKITS HGVSIEWTPP DGAISQYEVG ISDAEPIYTN
ETVHTFTNLL PFKNYSVYVA AWSGTERSFA LTKSFMTSED KPGSVSFFNL GAIRPTRLQA
RWGPPEFPNG ILTNYLLDYR ESDGSAPWTQ LSFPATNLSS VLALTPGKTY ALRVAAVNKA
GIGPAQDGSM TMPLGPPVLA RSAVRPGLVA ATKNTITLEF SRNDFLNSNG DVVNYTVIVA
EEPIGNLSAN LLSWRDVQGF PTWPPYQALE SFNPFTESGH LVAAVSRSLS DADKIQVVVG
SDQNCDSSKE KYCNGPLKEN SKYYAKLRAF TSLANENPMY TDTIYTDAIS TEGFSRNGAL
SIALGICIPI ILIILLVIFI AMMRKRNWGP FVKRARKAPH KTVEDKISIA ESITDKSRPV
RLRDFAEHVR AMSADSDFKF SEEYEDLKHV GRDQPCVAAD LPVNRAKNRF TNIAPYDHSR
VKLSSTDDEE GSDYINANYM PGQNSPREFI ATQGPLPGTR DDFWRMVWEQ GSRAIVMLTR
CVEKGREKCD HYWPDILYGS TDPVLYGDVS VTVLNESQFS DWTTRELRVV KDDEPARSVR
QFHFTAWPDF GVPERLQTFI KFIRFFRERV PLNSQPIVVH CSAGVGRSGT FIALDRLLQQ
IETQDTVDIF GMVHDMRKER VWMVQTEQQY ICIHQCLLCV LEKREEDPDA FDTGVHANPA
YEISDEDEGI VESGPF
//
