ID A0A1D1VDG3_RAMVA Unreviewed; 1845 AA.
AC A0A1D1VDG3;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Unc-13 {ECO:0008006|Google:ProtNLM};
GN Name=RvY_09005-1 {ECO:0000313|EMBL:GAU97767.1};
GN Synonyms=RvY_09005.1 {ECO:0000313|EMBL:GAU97767.1};
GN ORFNames=RvY_09005 {ECO:0000313|EMBL:GAU97767.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU97767.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU97767.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU97767.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU97767.1}.
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DR EMBL; BDGG01000004; GAU97767.1; -; Genomic_DNA.
DR STRING; 947166.A0A1D1VDG3; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd08394; C2A_Munc13; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF12; UNC-13, ISOFORM E; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 3.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..97
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 679..729
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 785..909
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1220..1363
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1471..1625
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1640..1767
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 163..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1802..1845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1845 AA; 208533 MW; 92F86F79E92AD017 CRC64;
MSLLCVTVKR GRLNGPPDRF NTYVTLKLEN VKSTTTAVKG SQPCWEQEFI FETNRLDTGL
AIELWNKGML WDRLIGTYWW PLMSIPHSNV EGPGKWIFLD VEFNLHDGEV VGTHFPSGHS
LHIDSRFELP NDIPEAEAME LQKKLAVLNQ IMDQELQTIQ KQQRQKAPYV QNGISEDSDY
TSDVNFPVHH HHQNSSASQY ASSFRRTDRP PMQKQRSALP PYYPPVVNKA PSFEDSSFET
QYPPEQHGHD RHQYPEDTRS VHRSNSNASE VLYYNSRPKD RLHPAYQDSR TPSPDVPAYQ
DEPSPVEVDD RRMDGRYSRP SLGYGNFPDR QERLSFQSEQ YYEEDEGDHH ADIASLPERP
DDISRDRRFS NHLSVEHDRL DDNLASPEPS YQSSFENHDG VPHSSRYISE RGDTLESTFS
HPDYQSEEHW DRSEDPPETF RPGSSYEQEA GLSTDETILG IDQNESDRPE TVTPASPLVP
EQVLCPPEPL VLSPPESKPP TVPQVVVEDT APTEVAPRPL SPVTILVNGS LDGLKYQGSA
KMRWLGAYAK IAAQLNPNNS AAGDSQKLNG SAHADSNPLY SGIDAMPDIR RPRRKNNLIG
DMVRKYRTGL SVCQIRRCCL IGFLPLRSGI QVLQTMAAKK RSTALTAFAR PSLNDEDLKQ
HVYKKALQAL VYPISSTTPH NFSPWTATSP TYCYECEGLL WGLARQGVRC SECGVKCHEK
CKDLLNADCL QRAAEKSSKH GAEDKKEGIV TAMKDRMKIR ERNKPEIFEL IRKVFGVDKK
NHANTMKNVK QAVLEGTAKW SAKIAITVIC AQGLIGKDKT GMSDPYVTVQ VGKTKKRTKT
VSQELNPRWD EKFYFECHNS SDRIKVRVWD EDNDLKSKLR QRLTRESDDF LGQTIIEVRT
LSGEMDVWYN LEKRTDKSAV SGSIRLHISV EIKGEEKVAP YHIQYTCLHE NTFYYLTEQA
NGEVRLPAPS KGDEAWKVYF EETGQEIVDE FAMRYGIESI YQAMTHFHCL STKYMCPGVP
AAMSTLLANI NAFYAHTTAS SAAVSASDRF AVSNFGKEKF VKILDTLHSE LKRDLQAYRT
NFPASSVAKL HDLKSTVDLL TSITFFRMKV QEVVNPPRAA SVVRECAVAC LEKTYAEYFK
NCYDMYNQEF QTEEGNEGPV TQEMKEPRLD SLTFWQNLIS LIVGIIETDQ QAYASVLNQF
PQEFNIGQLS AATMWKGFST DVKNHLEEHA QHGTCPNVDY INLHFRIKWV YNTFIADVPP
YKGQVPNYPA WFEPFVFRWL NENDDLSIDQ MRKAYERDKR DGFQPNSEHS LFSTSVVDIF
TQLNQCFEVI KKLEVPDPEI VKRYMTRIAK IINRELVTYA DIVKHEYPQF LHNEKIACTV
MNNIQQLRVQ LEKMYEAMGG EKLDPEAAEI LKELQNKLNV VLDELSLTFA NSLEPRVGKS
VQELSKCLAQ VKGNEKQPSG APRTTVQNEA DVILAPLMDF LDGSLSTYAQ MCEKTVLKRL
LKELWKLTIK GLEKMVVLPP LSDYKSILPT GKVEDMSRMV LNQVVTGKGL NLTGVVEQLS
KEMEKSLSPR QCAVVDIALD TIKSFFHANG QGLKKSFLEK SPELQSLRYA LSLYTQTTDS
LIKTFIKTQT TQDAPSQEES FGEVSIQVEL FTHPGTGEHK ITVKIIACND LKWSTTGMFQ
PFVEVCIVGP HLADKKRKFA TKSKSNVTSP KYAESTVFIL GNEDEPDAYE LHISVKDYCF
GRADRLVGTA VLQLKDILDQ GSVACWCPLA RRLQLNDTGW TILRILAQRN NDEVAKEFVK
LKSDTRQEAE VAPPAPPAGA TTGKPAASPN AQPAKGPAGP VKKGK
//
