ID A0A1D1VEH3_RAMVA Unreviewed; 816 AA.
AC A0A1D1VEH3;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=RvY_08607 {ECO:0000313|EMBL:GAU97283.1};
GN Synonyms=RvY_08607.2 {ECO:0000313|EMBL:GAU97283.1};
GN ORFNames=RvY_08607-2 {ECO:0000313|EMBL:GAU97283.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU97283.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAU97283.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU97283.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU97283.1}.
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DR EMBL; BDGG01000004; GAU97283.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1VEH3; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF73; INCREASED SODIUM TOLERANCE PROTEIN 2; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 184..205
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 259..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 332..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 398..422
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 522..549
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 592..615
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 30..164
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 167..785
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 816 AA; 93074 MW; F01E867C23857F18 CRC64;
MYTLCLNCAR LSANVCTRLI SPKFTLQDAS EIKYVEAKMA RLLPKICQID TSILPPKPHF
VSTAFSKQKE NLFKIPHDES QFFSPLQRSR LLWEALNRIQ STDPHHDQLS MGSLLANKTY
LAVYPLHDGS CEDDVRPTKD HQTSRAALFD QWGRFRKFYK LQPIDHIKNY FGERMGFYFG
WMEFYTLMLL PAAVVGLLCL LFGAFSMGSS VSVHEVCHSD STVGDTVMCP ICNKRCSFWR
LRDGCVNTKL AYLMDNPSTF AFAMFMALWS SFFIVLWKRR QTLLSWSFDT FDVTEHEEPV
RPELMRKIKP EKWRENPITG IREPYVPGGI RALYGFLSSV AVVFMVLLVL AATTALVVYR
IVLNVAIEAS ASPVGTGNFS SMISSPAFQP FAVRNSGLIV AFSASILNLI VILALSNVYY
FLAKWLTERG KCKIFHVTRS VHKLCMVRLH AVEMPRTQTE YQDSLTFKYF AFDFVNSYTS
LFYVAFFKGR VPPALPGAQG HLGLPVDRVQ CVKGSCLLEL TIQLMVLFLG TTTVTFVKEI
IYPSVLRYFR REKRRRLSML KSVETRWKRD NDLLPFPPMG LFKEYSRMVK QFGFITMFVA
AFPLAPLFAL ITNLIEIRLS AYKYLTLYRR PIPLWSRNIG AWDDILSNLS RVAIITNAFV
IAFSTDLVPE LVYLLAFSED GSLHGYNNWR LSDFAVTDYA KSAMPATVVS SFNSSELPDS
CWYREFRTGP EESIPYTLST VFWHVLAARL ILVIVLEHFI IVLTKIVAVL LPEVPTALRI
KILRENYRAR EALYGSEETG RGNLCTSRSS SENPLS
//
