ID A0A1D1VIK9_RAMVA Unreviewed; 753 AA.
AC A0A1D1VIK9;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:GAV01452.1};
GN Name=RvY_12162-1 {ECO:0000313|EMBL:GAV01452.1};
GN Synonyms=RvY_12162.1 {ECO:0000313|EMBL:GAV01452.1};
GN ORFNames=RvY_12162 {ECO:0000313|EMBL:GAV01452.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAV01452.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAV01452.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAV01452.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAV01452.1}.
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DR EMBL; BDGG01000007; GAV01452.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1VIK9; -.
DR STRING; 947166.A0A1D1VIK9; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd18820; GH43_LbAraf43-like; 2.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR43817; GLYCOSYL HYDROLASE; 1.
DR PANTHER; PTHR43817:SF1; HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED; 1.
DR Pfam; PF04616; Glyco_hydro_43; 2.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..753
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008898449"
FT REGION 659..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 33
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 211
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 150
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 753 AA; 84983 MW; 02D30DAEFD85A77C CRC64;
MEMFSSLFFL TSLFLFSNAE TFRNPIKDGD APDPWILRYN GAYLLSHTGY DEVVVYQSDR
ADNWRGAASV TAWRPLPAFN DFTEVWAPEI HFIRGNLYIY FTANPHSNYS FSSNGHRMFA
LQADDPSNPL GTWTFRGRIF DPRKDIWAID GTILQHQSGK LYFIWVGGFE FDGLTTYISE
MGDPLTVVPG STILLNRATL PWETQDGNVS EGPAVIDSGD NYYVVYSGTS TWSDNYNLGM
LRINKTKDPM VIGNWYKNPE PVFVKNVTEG VYGPGHASFT VSPDGTEHWM VYHAMNKTYA
DGNWRQARIQ KMSVDSQGVP VFPEAVGFNR ELEVPSGSPK MFRNPILDRD APDPWILRYN
NTYLMTFTMH DCIVIYQSDK LEDWRNATTA TIYTPPPNMY YELWAPEIHL IRGNLYIYYT
ATTNRSGTEG HRMYVLRCND ARNPLGNWTF EGKILDPICD WWAIDGTVLQ HVNGKMYFIW
AGRWEYADWT TDHLLQLLIA EMSDPLTIIR GSTRLLNRPA LDWEMHGDEV HYGVSEGPAV
IETENYYHVP YSGSSTWTNN YALGMLTINK SADPMIATNW NKAQRPVFVT NEAESVFGPG
HASFTVSPDG TEHWMVYHAM DRMYQEGNER YPRIQRFTIG KDEFPVFPSQ AAGFARDLAV
PSNSSRDSTS TSATMTTVTL PSVAPPSSTR FPTSQTPLAV TSTPRPSNQE TTTPIATSTP
TSSSSRSTTP SFATCSTGGI ILLFSSITLL WVS
//
