ID   A0A1D1VIL0_RAMVA        Unreviewed;      1072 AA.
AC   A0A1D1VIL0;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=GAF domain-containing protein {ECO:0000259|SMART:SM00065};
GN   Name=RvY_10865-1 {ECO:0000313|EMBL:GAU99932.1};
GN   Synonyms=RvY_10865.1 {ECO:0000313|EMBL:GAU99932.1};
GN   ORFNames=RvY_10865 {ECO:0000313|EMBL:GAU99932.1};
OS   Ramazzottius varieornatus (Water bear) (Tardigrade).
OC   Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC   Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX   NCBI_TaxID=947166 {ECO:0000313|EMBL:GAU99932.1, ECO:0000313|Proteomes:UP000186922};
RN   [1] {ECO:0000313|EMBL:GAU99932.1, ECO:0000313|Proteomes:UP000186922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAU99932.1,
RC   ECO:0000313|Proteomes:UP000186922};
RX   PubMed=27649274; DOI=10.1038/ncomms12808;
RA   Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA   Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA   Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA   Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA   Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT   "Extremotolerant tardigrade genome and improved radiotolerance of human
RT   cultured cells by tardigrade-unique protein.";
RL   Nat. Commun. 7:12808-12808(2016).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|ARBA:ARBA00001968};
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family.
CC       {ECO:0000256|ARBA:ARBA00007648}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAU99932.1}.
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DR   EMBL; BDGG01000005; GAU99932.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1D1VIL0; -.
DR   STRING; 947166.A0A1D1VIL0; -.
DR   Proteomes; UP000186922; Unassembled WGS sequence.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF00233; PDEase_I; 1.
DR   SMART; SM00065; GAF; 2.
DR   SUPFAM; SSF55781; GAF domain-like; 2.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186922}.
FT   DOMAIN          292..527
FT                   /note="GAF"
FT                   /evidence="ECO:0000259|SMART:SM00065"
FT   DOMAIN          551..715
FT                   /note="GAF"
FT                   /evidence="ECO:0000259|SMART:SM00065"
FT   REGION          351..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..403
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1072 AA;  122697 MW;  E381CC97EC2F28B2 CRC64;
     MTATADAWRV EDRHDAYDFE DDPGGAPPKI DMECSADGKC ARATQTLGKV PKVYLTEAWK
     YMKIAGRENR PVVDFRHYPQ IGTMRTDKFQ PVVPDNVTLE ELEQEPSLLR VIRENHHMTN
     HTIADHFDAS ARHCMHLGNF AQLRVDPTYN ALVNAMPTTK SDLWFATNTK SVENQLMSNK
     VMVKEFIKQS KLFSSRDLYL MMHLKRARRK PIEGLKAKAK KEYRDTREAD IHAIEQYEMA
     SDRRESHLQA YAPQNPQERA IKDSNMYHLP PDSHLTHELP EFKQFKEPSV VNLSEAMNEV
     FHYAKRQKNL LNADQMAFYV VRETDGPIVS LEKYPPRRVS QYTQPIPESL QYGMSLSGAS
     GKEGGTEVGD APNGVSGSSR DVREREDSGA VSNVEKLEDD LDLSDTQNDG GEPVKSPPKI
     QKQRTSDIVV DYREPHELIT KVVTAQTWFL IPNVKAYLSR YPPILPVMPE DPRSIILVPV
     GLHSGKIIGF LSFIRCGRKP TFTESEADIS FVHANYLLRT RYYAGVRSVQ RQTERNMLKY
     MHDILKIKDP PVEEFLHQTL ILARTLADAD RAGCFLANQL TESLSLDRQL IVYLLESGGE
     DPVTGKPACR KGCDIRMSVN SGIVGCAYRH RRTYSSSGTQ FDQHFFSAID KMMAHRTESL
     VCVPFLMGGE PYGLLEVLNK KSSSRFSDQD IAMLHLNSVF PALGILIAWY RVACNKQEYL
     WCIYRARIAS MRNRRVHRTT RLWRPQERPR NLPNFANLTP ELTEPGYFYL DAMKELTETC
     AAMIKSMAGE LKLDDTVVWN FVHHVKNYYT GAKFHNWRNT FAALQTLYAI MSHTNGFFSS
     EEQLTMAVAV MVHGIDHCLL NGAITEGTDL PGGLAHVYGI TIPEAGSVRS MSILLREKST
     NVFHMFRSKY WRRLKENARN CVLATHLPGV PQKTAKLKAL WTAGEFKSFE IEHRQFLREL
     VATFLRRFCV PLFDLLRLIF PDTGVFLDAC VKNLEKLDPE SRFDQLSTLS HIDGGGTGHK
     RKDRHVSSEM KRMMRRNIWE DMRIPFEQRD IEYKNFADMP HLWHKSEAPQ DS
//