ID   A0A1D1VLC4_RAMVA        Unreviewed;       978 AA.
AC   A0A1D1VLC4;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=3'-5' exonuclease domain-containing protein {ECO:0000259|SMART:SM00474};
GN   Name=RvY_11370-1 {ECO:0000313|EMBL:GAV00538.1};
GN   Synonyms=RvY_11370.1 {ECO:0000313|EMBL:GAV00538.1};
GN   ORFNames=RvY_11370 {ECO:0000313|EMBL:GAV00538.1};
OS   Ramazzottius varieornatus (Water bear) (Tardigrade).
OC   Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC   Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX   NCBI_TaxID=947166 {ECO:0000313|EMBL:GAV00538.1, ECO:0000313|Proteomes:UP000186922};
RN   [1] {ECO:0000313|EMBL:GAV00538.1, ECO:0000313|Proteomes:UP000186922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAV00538.1,
RC   ECO:0000313|Proteomes:UP000186922};
RX   PubMed=27649274; DOI=10.1038/ncomms12808;
RA   Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA   Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA   Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA   Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA   Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT   "Extremotolerant tardigrade genome and improved radiotolerance of human
RT   cultured cells by tardigrade-unique protein.";
RL   Nat. Commun. 7:12808-12808(2016).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAV00538.1}.
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DR   EMBL; BDGG01000006; GAV00538.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1D1VLC4; -.
DR   STRING; 947166.A0A1D1VLC4; -.
DR   Proteomes; UP000186922; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR47765; 3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47765:SF2; EXONUCLEASE MUT-7 HOMOLOG; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022839};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186922}.
FT   DOMAIN          673..867
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          293..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   978 AA;  109069 MW;  BED20ED0B55E971F CRC64;
     MQSSNPRRGR GFGRGRAGYR GGYRGNQMAP SFSGSTGPSP AFATQPSPSL VCPPGSITTI
     WNPSISALPS GLASSTVYTS ASVPLPHNSR NLRPVYDPLS TYPTPSGSYF PSRHNYPAIQ
     HNNDPSQFPL LSIPNGQSNF RQVNQQTVPQ PPYQSMVYHQ MPAGPETAGG GVYTVGGLTH
     QPSVLVHSCS TNQSQMPFHQ PAYRTNQPRP SGSGQQFHQG NARNQPNMAY STVTAGAPSV
     ISYNPNTIHI DLSGMNRPNG IIQHTPRPQY AINSNNSPKA VSTTVLPFAH RPPDCWPRPA
     SQSQTLPSQP LPFDSRLPQQ ASHGLVPYQY GPAQTQTWNA NGANFQQISV QAGCSNPQFQ
     PQLQPQHSQD TYSPQPAPPY QYSSQLQFHG NVQIPFVQPH YSGQYSNGSS NLRFVDGYSR
     PMIPTDLNNP QSQRAIKNFT PEQLIDMRWF REAAVKITSC KQQDQFSLAT IAHPLLCSGD
     THLLEKYVQN SPDLQVQLLE MLERLFSDRN YIQEIYQDYG TDYCNQNRCV LSIQRIKKLA
     TQWLNRFYAD PAIISSIYLD KCQAALAYLI KNTDADSISY EAWLENVEDL VKPFPDRLKS
     FALHQLYKKH KLYHLTDLME SWGWNMWEGR TIPELQQYAA ATQVAQAEKA PKVYHECGLA
     REAIEWVDTL EYFHAALTAI EEEEDCVIGL DCEWNSSRTG FEDSSLALLQ VASRNKCYLL
     DVHTLKHEAT EGDWGHLANV LRSPTIRKLG FDFGQDSQML KPFLPRQPNG FSPQENNVID
     MKSAIECIVR EIPDLFMSKD GEDPQIILEM RFALASVVEL LFGAPLMKTE RMSNWERRPL
     REAQIIYAAT DAHCLLQVYD YLTELCQARN VQFPPKSMLR PSKQAKKDFK VQNGSGLNPT
     VLDLETEVDS GILDGAPAPS SPRADESFSL GVDQPDWTAE ITFSSNESGN SYNDPSPTQL
     AVPIGHNLNE VPSDLIAT
//