ID A0A1D1VLJ5_RAMVA Unreviewed; 1179 AA.
AC A0A1D1VLJ5;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN Name=RvY_12367 {ECO:0000313|EMBL:GAV01696.1};
GN Synonyms=RvY_12367.2 {ECO:0000313|EMBL:GAV01696.1};
GN ORFNames=RvY_12367-2 {ECO:0000313|EMBL:GAV01696.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAV01696.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAV01696.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAV01696.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAV01696.1}.
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DR EMBL; BDGG01000007; GAV01696.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1VLJ5; -.
DR STRING; 947166.A0A1D1VLJ5; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF21; CYSTS, ISOFORM C; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922}.
FT DOMAIN 201..390
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 847..944
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1002..1024
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 130033 MW; F36E80430661B57E CRC64;
MGQRRRLNST GNDLSSDELQ PPLNGKSSPS VMLEPQQMAV EHGDEGSRLQ PTLPPQSLKR
LSVPASYPQH TKSTGLGAAQ SDSNLSPSSP SGGGSSSVLR RPISPSGFSR WRHVADKLLN
KSGSTDSQGA DYDSPAEDVS LSEPTSQTGA ASAAGKADSV IHLLPMLRFD GDLRLELDEP
EAWVSLVEPS VLGQLPEEEV KRQSMIHELI FLEKNYQIIL LIIDQLYIAG LQRELQWSEA
DVRLFFPSFE GIVSVHKTFL GRLRARQAQG VVIVQIGDVF LQQFEGDEAE KMKRAYADFC
CHKKQAEAEY KQRLKTDAKF AAFDKKWNEN IGNRNLRFDS VMQTITQRIT KYRILVDNIF
KKTNKSSGDY GLMARACHYV DDVISHVNRE LDQQKLKEEL GRIYRSFDSK STLVGRDGTP
YGPAEEWKKH NLLDRRTLLF EARQVQIQRS SKEEEKKALS VTLLVMSDVL VLLSNSAGRD
KYSWASIDSK RDRAVIHLQD LVLRLKPETA GAEERSLYLV SQELRTPYEL TCETAKERDK
LRKEIEAARD HGGNLRASSA MDGDDLADAL FLDNYTAHIK RIDDVVAACR LRDDGIRRLC
LEKEQLLQQM ASCAGMTNYR LHRPPLLDME EGNLQEGGEE LLQSAQEAVR QADKLCCFLT
AAALPSEGQG QRRDDGKEEV QRRIPSWPYG ELLGQASPEP LPTVHLGVSA QAPARRHETF
GGFDNKSEMP ALTSTAGRST SMKNPPRQRR SASPLNGTLS PACQPEQSEA QAVPLDQVSL
AVSRTSLSPS TLSGRESGDG SSPSASSSPR LSAVLSDEQA TLVPALIQLA HHLNQLTDGL
AQHLTAVEAL RHKYAAAQHK MAVMEGRDKR LNKHSGQLEE LRALQEALAR DKCQWQAQRD
DERQQLDKLR KQLDADMMKA KQEREDVEKQ RQAMFAQCEK LVENGLEVKL SSSAPYAQIF
HRQQPPPEAA MSSELLLQSL AETGPLLEQD PRLAHLPPRP LSHQPAHYPP PLSTDGPPLQ
RLTSPPPLAA VLANGGPRSA LAARSLLLPF NSFSSLPVAP ALDTGATPPP SGLCGPAGRQ
PSQSSLLLPT GPPVLPKHSF SWKGSMESLC DKLRNPREGS ALAPADRPDS AAPPRPTLRA
NSEAKLGIGN LMHLSEKDQA LDHPPSTRKK GSAKKRYAF
//