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Database: UniProt
Entry: A0A1D1VMT0_RAMVA
LinkDB: A0A1D1VMT0_RAMVA
Original site: A0A1D1VMT0_RAMVA 
ID   A0A1D1VMT0_RAMVA        Unreviewed;      2298 AA.
AC   A0A1D1VMT0;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   23-MAY-2018, entry version 10.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:GAV02136.1};
GN   Name=RvY_12738 {ECO:0000313|EMBL:GAV02136.1};
GN   Synonyms=RvY_12738.1 {ECO:0000313|EMBL:GAV02136.1};
GN   ORFNames=RvY_12738-1 {ECO:0000313|EMBL:GAV02136.1};
OS   Ramazzottius varieornatus (Water bear) (Tardigrade).
OC   Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC   Ramazzottiidae; Ramazzottius.
OX   NCBI_TaxID=947166 {ECO:0000313|EMBL:GAV02136.1, ECO:0000313|Proteomes:UP000186922};
RN   [1] {ECO:0000313|EMBL:GAV02136.1, ECO:0000313|Proteomes:UP000186922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAV02136.1,
RC   ECO:0000313|Proteomes:UP000186922};
RX   PubMed=27649274; DOI=10.1038/ncomms12808;
RA   Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA   Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA   Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA   Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA   Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT   "Extremotolerant tardigrade genome and improved radiotolerance of
RT   human cultured cells by tardigrade-unique protein.";
RL   Nat. Commun. 7:12808-12808(2016).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAV02136.1}.
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DR   EMBL; BDGG01000008; GAV02136.1; -; Genomic_DNA.
DR   Proteomes; UP000186922; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000186922};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      164    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    337       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      346    404       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      587    817       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1024   1230       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   2298 AA;  256501 MW;  E94E452DFE1A1E28 CRC64;
     MGDHAESEAV SSEQDDVSFL RTNDVVCLSC TQTAKDGGSG TERVCLGAEG FGNRYCFLET
     VSDKNYPPDV ASCMLVIEQA LSIRALQEMV AAAGNEAGSQ SGHRTLLYGH AVLLRHVNSD
     MYLTTLDTSS SSDKLAFDVG LRETAQGEAC WWTIHPASKQ RSEGEKVRVG DDLILVSVST
     ERYLHTLRTP ESSVIASFHQ TQWTILPVAT GSIKAKSISF VFSQEIIRFF HGQDECITIP
     ETWADHPQHN HVVYEGGDAL ERARSLWRVE LVKGKWTGAF LNWKQPFRIV HITTGRYMSV
     KEGGTVSLVG RDKAKLDETA FFLKANKDDK SFGLDDKEKE EEGMGPANIK YGDTFFYIQH
     ATSGLWLSYQ SNEVTKRGVG KVEEKIAVML EEGHMDDTLT FSRAQQEESK SARVIRKCTY
     LFSKFNNGLD ALLRQPVDRR TSMSSAVPSS YNLKEVVDLL KDLIDYFAQP VHGTGHEAKQ
     THLRALKNRQ DLFQQEGVLT LVLDTIDKIS GLANSGYMNS LQSEDGANEA LLWEEISSFL
     YLLIAAMIKG NHGNCAQFAQ SARLNWLFSR LTQQGSEGVL DVLQSVLTDS PEALNMIRED
     HIRGIISLLD RSGRDHKILD ILGNFCVGNG LAVRSSQNNI CEFLLPGKDL LLQTKLVDHV
     SSVHPNIYVG FTDGSAMFRK WYYEAIIDHV ELASNLPPHI RVGWANTDGY YPYPGGGERW
     GGNGVGDDMF SFGFDGTNIW TGGQSRAVRM YETDFGFHKG DIVGCNIDLT IPEISFSLNG
     VRLRATIRNF NTTGMFYPVI SMSARTSCRF MLGGDQGRLK HGPPSGFSSV IESLPPKETL
     RIEPNFYFGE IQRSLLAGPA VAQENSTFVP KPIDTTGVNL PNYILQIRDK LAENIHELWS
     VMKIEAGWTY GDVRDDHLKT NPCLTNFKNL PIAEKNYDMT LSMETLKVLL ALGYHISMTP
     TDNRIRPMKL SSTYTQPNGY KPAPLDLTNI QLTGPMEELK ELLAENIHTV WAKNRIDQGW
     TYGLSQQNVA KRSPHLVPYD SVEDSIKEMN RNTATEVVRT LIAYGYGIDP PSGEQKVPTK
     AAQKQSSDKL QSRSYRAEKT YAVTEGKWYY EFEVLTPGYM KVGWALVGCL PSVELGVDDQ
     SYAFDGSLGR KWHQGSEPFG KSWQTGDVVG CLLDLNDHTI SFTINGELLV DPSGNEAAFE
     GVVAETEGFV PACTLGGGQR ARFNFGQDIH SLKFFTTSGL QEGYEPFCVN MTRPVPFWYN
     RDQSVFVPVS DTNSMLEVIR IPGSGNTPAG LKLSRKSQGL TDNTQMEFLR LSLPVTTRSH
     YMSYEEKHQQ MVQVEEARRM QKSTAATVQQ RNKMEEQMIT GGFSVNDIQG LTAQDRFSRE
     QSEDTMDAMM GDMVDEAPRI SARMSLSAAP RASLGVDKNQ RQRGIMKKTQ SLEVAESPDE
     PGTSGGVTFM QPLSNKRMPR SASEDRFGPN SRGPTASSRD PSLSMVNIDC CTFDHSAPGP
     DGKLKKRSAS PFSYITKKIK EAKHRSVSKE RLDKTTLPGG LRTPDITLAA GKSGGPSISL
     RIPDQQQSFE SGDMVGNGMN SQHVAFGFDN EAVRPSSTDS RYEADMDVAN SNLFDLISEY
     NYSVRIFPGQ EAKQVYMGWV TPDFHHAERP FSMESIRRAE VKVLDVGGQL KDHCFFQNSY
     LVSAGELQEQ ATSQGVQEKG RGSSTPGIVI SSSIDVATGL LSFSFNGTEI EDRYQVEPGT
     KLFPVVFVEP TSRDVVQFEF NGTKTALPLS SALFHRDHSM VSQCPPRLRV LTLQPYHWSR
     VPSQALRVHE LKMSDVRGWS MLCDNPVSML AVYLPEEDRC IDVLELIENE ELLQFHARTL
     ALYSSICSHG NHKVAHALVN HVDQKQLLFA IQSPYLSGAL RQAFHDLLVA LHLDFHAKAM
     FNTRDEFVIP VKKRVDGRKG GRGGLMRQQS SINPAQCTSL RPLLNIRDKI SSAGEDQVDI
     KNMTAPSFPL STLKTHIMDA LADGVQKGTS HSRDPIGGTY ENFFVPLLKI VDQLLLIGFL
     NQDDMDRLLN MLDPTKFTSQ IHNGLNGRGL VHMQLDENVK LQLCYVLQDL CDDRIRKRIE
     ELVAFSEEYV GKAQADQLHR YVEIKQEDLP ASIAAKKTKE FRCPPKEQMK MLLAFKNVEE
     EESASCPSPE EVRAELTDYH SALVARLGPQ PEEKVTRFTR SFGFSNEVLT DMIKQSIIRW
     AAESQIESQD LIKEMFSLMH RQYDGIGEML NAMKKAYVIS TANVTDVTNM FTSLVRIRTL
     LSVQMGPDEE EVLRYSLW
//
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