ID A0A1D1VMX6_RAMVA Unreviewed; 842 AA.
AC A0A1D1VMX6;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=TSP C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=RvY_11139-1 {ECO:0000313|EMBL:GAV00264.1};
GN Synonyms=RvY_11139.1 {ECO:0000313|EMBL:GAV00264.1};
GN ORFNames=RvY_11139 {ECO:0000313|EMBL:GAV00264.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAV00264.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAV00264.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAV00264.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAV00264.1}.
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DR EMBL; BDGG01000006; GAV00264.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1VMX6; -.
DR STRING; 947166.A0A1D1VMX6; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 4.10.1080.10; TSP type-3 repeat; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR InterPro; IPR017897; Thrombospondin_3_rpt.
DR InterPro; IPR008859; Thrombospondin_C.
DR InterPro; IPR028974; TSP_type-3_rpt.
DR PANTHER; PTHR10199; THROMBOSPONDIN; 1.
DR PANTHER; PTHR10199:SF100; THROMBOSPONDIN, ISOFORM A; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF02412; TSP_3; 7.
DR Pfam; PF05735; TSP_C; 1.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF103647; TSP type-3 repeat; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS51234; TSP3; 3.
DR PROSITE; PS51236; TSP_CTER; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00634}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 118..157
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 198..236
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 296..338
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 436..471
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 495..532
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 533..568
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT DOMAIN 608..822
FT /note="TSP C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51236"
FT REGION 369..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 307..324
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 842 AA; 92004 MW; 7AD1403C52A3A01B CRC64;
MHSMLRDMDD LRRELKLVLH EMRDLRRMME DCELCPPKAK PNPCDAQPCF PGVRCEPLDG
SYRCGPCPPG YKADGRTCQR DYCDPNPCYS GVQCQSGADG PRCGPCPSGM LGDGRDCRRN
LCEANPCYPG VQCQQHGDAY TCGSCPAGYA GDGKRCNRLT TCADRPCFDD VPCYDSPDGY
RCGSCPRGYT GNGTHCRDVD ECQQARPCDA RTQCTNTIPG YHCSRCPTGF MGDEVDGVDL
EDAQQNPQKC RDIDECLRDN AGCVPNSNCL NTEGSFTCGP CERGYTGDQS RGCRKLDGLC
PDGVTACDKN AICFRRRGTT GYTCQCKVGY AGDGNNCGLD SDLDGFPDEE LPCAELHCKA
DNCPKVPNSG QEDADLDGIG DQCDPDADND GILNVDAQDN CPLKANPAQE NSEAEDKDRY
GDACDNCPFV ANPTQTDTDS DGDGDECDPD ADGDGVLNKV DNCPLVPNKD QLDADKDGVG
DRCDNCATKA NPDQKDQDKD LVGDVCDTND DRDRDGVQDS IDNCPDIANS DQIDSNDDGK
GDICDDDKDG DTVLDGKDNC PLVANPGQND YDDDGKGDAC DDDWDGDGVL DRFDVCPDNK
KIYKTDFRTY QTIALDPEGE SQIDPLWIIL NEGAEIYQTL NSDPGLAVGY DAFTGVDFGG
TFFVNTNIDD DYAGFVFSFQ DSSHFYTVMW KKAAQKYWST TPFEASAEPG IQLKLVASKT
GPGEVMRNAL WHTGNTTDEV YLLWKDPRNI GWKDKTAYRW ELVHRPRLGL IRVRFFEGVE
VVADSGNILD LTLMGGRLGV FCFSQESVIW SDLVYRCNDG QPTFFGLKLP AASNNTGPNI
LL
//
