ID A0A1D1VRW4_RAMVA Unreviewed; 905 AA.
AC A0A1D1VRW4;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Phosphatidylinositol 4-kinase beta {ECO:0000256|ARBA:ARBA00039877};
GN Name=RvY_14613-1 {ECO:0000313|EMBL:GAV04312.1};
GN Synonyms=RvY_14613.1 {ECO:0000313|EMBL:GAV04312.1};
GN ORFNames=RvY_14613 {ECO:0000313|EMBL:GAV04312.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAV04312.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAV04312.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAV04312.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00036767};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19878;
CC Evidence={ECO:0000256|ARBA:ARBA00036767};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}. Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004450}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00037860}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037860}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAV04312.1}.
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DR EMBL; BDGG01000010; GAV04312.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1VRW4; -.
DR STRING; 947166.A0A1D1VRW4; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 623..890
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 39..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 905 AA; 100896 MW; 65A34423E8A69D73 CRC64;
MEESDCKRFK SSSEFFPSES VEHDVSDLCG SVASFAVSDT SSSPSISETT HVNPADGSSG
AATSIINVTS AFKHPSILRS LSDKLPHNYR RTHRRTGSSQ STSSLNWLSQ VDESHELTES
DVHPDKTLSA PNVLGLYLTG ESPYSASSLN DTVDGNASHS PVDNEVTAGL QPTTPPPSQE
HTNWLLRFFQ SELFDASLAL HYLYRSKSKD TGVQQYLGNR LFTLDPVDVE FYLPQLINLC
IDTRDLSDYL LPYLKYRCEF SPDLALRSAW LTDAYTQDGW MRGRKIRKTP IAKFREAILA
ETYSCRPVRP LPALSALPTL KPLREPEPMA TMTPPGSVKK TGHHRSRSDI TGGSTTTSSA
APPAVAQHPV KSTIGDLASA KAFHSGCTCF ESTVNVMHEL KGEPVVCTCQ APRLAPEIEF
VKALVKIGRN LTRSPKDGRT VRLAADLGVI NINLPARVWL PLYCDTPHHV VRIPPTAAAV
LNSKDKAPYL IFVEVLLVED LFCTPVNSKI QDNVMRHTKS EENIMDQSPC DEGISSSKSD
EDGECWSQED DEILNQFPVH DVNRLHNGET TSVWSQESMQ SLESREITIS AGDVVRRLNE
SLNANGTSFK PDHEDPSAAA MKEPWEMKQA RIRRSSPYGH LPNWRLLAVI VKCGDDLRQE
QLAHQMLQLL QKIWETEKLK LWLKPCNILV TGKDQGMIEP IINAVSLHQI KKQSQLPLLQ
YFIREYGGQT TEEFFKAQLN FVHSLAAYCL VSYLLQVKDR HNGNILLDSY GHLIHIDFGF
ILSQSPKSLG FENSQFKLTS DFVDVLGGVG SDMFEYYKLE MLKGLIAARK HCDKILSIFE
VMQNADLPCF KNGGSNVVNG LKQRLHVYAT EESLQQMVDT MVSSSIASIT TKLYDDFQYY
SNGIM
//
