ID A0A1D1W7K9_RAMVA Unreviewed; 959 AA.
AC A0A1D1W7K9;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=DNA topoisomerase 2-binding protein 1 {ECO:0000313|EMBL:GAV09316.1};
GN Name=RvY_18880-1 {ECO:0000313|EMBL:GAV09316.1};
GN Synonyms=RvY_18880.1 {ECO:0000313|EMBL:GAV09316.1};
GN ORFNames=RvY_18880 {ECO:0000313|EMBL:GAV09316.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAV09316.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAV09316.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAV09316.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAV09316.1}.
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DR EMBL; BDGG01000021; GAV09316.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1W7K9; -.
DR STRING; 947166.A0A1D1W7K9; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd17731; BRCT_TopBP1_rpt2_like; 1.
DR CDD; cd17738; BRCT_TopBP1_rpt7; 1.
DR CDD; cd17728; BRCT_TopBP1_rpt8; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 5.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR PANTHER; PTHR13561:SF22; -; 1.
DR PANTHER; PTHR13561; DNA REPLICATION REGULATOR DPB11-RELATED; 1.
DR Pfam; PF12738; PTCB-BRCT; 2.
DR SMART; SM00292; BRCT; 3.
DR SUPFAM; SSF52113; BRCT domain; 3.
DR PROSITE; PS50172; BRCT; 2.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:GAV09316.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922}.
FT DOMAIN 233..322
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 721..813
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 959 AA; 103164 MW; D8AF4201272629D4 CRC64;
MARGGTPTST WQAQAGQRER DEPVASQRVQ EMRLVRCKGQ SEAERKSLQD LFEFIGGQSS
STTVQWIEEE EVLWAAQCQL TKGSLLAVAQ GCVYVMWPFG GAAFDVLKES KVPIYSPNCV
LTSIRQGFSL PRHLGSAIFS FALLRVNVCC SNMMAEAREE VYRMVQEMAG TTNKALTACC
THLITPVVGS VKYFAATEAG MRVMMPAWVG AVYKLAKAGQ DNADNLQQLS AKFATPIFAG
CFVSVSQLSQ EQRAQIRALM KEHGGRYDKD LSKATVTHLI CDVLVGDKCV AAASWKIPIV
HSQWVRHSVD KGYCLDYRKY LLTGPKSAAA NLTADQRVSG SSASSASQRA LTPDHVRQGP
NGLRATSTPH KNAQRLDVEL DISAIDKPVK TEDGAAAAAA AVPTKKEEEA GDSSGPQAKQ
AAVAHPAKNE GAVQSVVNEN DLSSSAAFPP PSPQPFRSSP QARPSVVVAA GTITSSVAGL
RVEAEEVKAE VLEKVEGSAG APCSSLLLAR RVMALVGQEN NRSGPTWAMP TSAKSSPANS
PSSAVPVADT FKTAPTGSKE VAQLRVQQEM AQLRQQLQMA KVTISGQAGP KMGRLTRRPS
NKGKKSPGRK DRGQVVWSQH ERQPFLAGEG GRDFKDDGGQ SEEEYEEGSE DEVAEVAVVV
AAAAANGQPL VKPPPTSTNS IVPLLRQAPA VGPLNSKRVA NAVEGPAVSR PKRPADIVEV
EQGQAAADKV FILSGIPADG EKQQIFDAIT KLGGRFIDTI QLQPQATHLL VKAPAKNEKF
YGCCATGRFI LHPSYIIHSA KAGHYLPEEE YEWGNVDKAA HLLLDLDDNN MKLAKAAHRW
RLHVSRGHPP AFTGWTVIVL AEQAVRGDGY IRMLKAGGAT VLPNTPPLLQ YVKRATHLLY
ESGKVAISRE EVEAFEAAGV ICNRPEMLSQ YITDQTPPII PPHLRHASHA LPPPKRSRP
//
