ID A0A1D1W7U3_RAMVA Unreviewed; 2065 AA.
AC A0A1D1W7U3;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Dedicator of cytokinesis protein 7 {ECO:0008006|Google:ProtNLM};
GN Name=RvY_19002-1 {ECO:0000313|EMBL:GAV09460.1};
GN Synonyms=RvY_19002.1 {ECO:0000313|EMBL:GAV09460.1};
GN ORFNames=RvY_19002 {ECO:0000313|EMBL:GAV09460.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAV09460.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAV09460.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAV09460.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAV09460.1}.
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DR EMBL; BDGG01000022; GAV09460.1; -; Genomic_DNA.
DR STRING; 947166.A0A1D1W7U3; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186922}.
FT DOMAIN 604..780
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1616..2049
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 425..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2065 AA; 233882 MW; F8895E8F665843ED CRC64;
MTESIARMAV AASVSANGQR RAFAQKLNKA QASEVRRQIK TQSGDLPLPK SLSDNSVTVS
PLSSQTAAAY VEVPEPVDYE DFFRAHQPTI DRDPLRHLLQ FPIDDIEVKT ISKKPRTGTH
VLPENTNGLN SRERDCIQEY TANYTVSYRR YQRYGPCEVL AETILRRDEK LDLIPRQVYE
CDTKPQPSPY PVSARTDADP RGSWASGAFD LRSSNAEPLV PGLFERLPAD DRDAIDRRKR
LEKRQPAIFT LYPAQDVEDQ IERRLVPPLP QEPSGHRILV KVLTMKLDLE IEPVFASMAI
FDAREKKRLS ENFYFDCNSD TTRGMLSGHI PAEDFSTLAR SCVYNVTYPT ADLVIIVRLE
KVLQQGDVTE ATEVYLKEDK NKEKAQNNAQ VFCERLGKYR MPFGWTAIFL SSIVQGAAPT
SSQLEMDVTS SSGTSVSYMG SQSSKSGSLD RTLNPLELLR KGKQMMTNTM SSVEQNGTLS
RQATRSNSLY TQDEPPPNLD AFRPVVVSLP TFFRHEPDKL SEDDLFKMVV DLKRPTSLTK
RLKCIPGTLK LEISPCVDGA VPPGCLTPEL APLVPVSEDN TQRPIKEVLE FPLYEQFQPH
YSYRNLLYVY PKSLNLSNRP GSARNIAVKV QLLGAEDCPL RAIFGKSTCP EYLFDGYSTV
LYHDKTPVFT DEFKIKLPPN LDDREHGYHL LFTFYHISCQ KKGSEGHAAE QIETPVGYTW
LPLFNVCGAD SMLINGDYNL PVMMEKPPAS YSRINPEVQL PGTKWVDNHK GIFNISVKPV
STIHTGDVKL ERFINLCAYI DNGRIPVYIG ESNIENNLKD AILDLVMAAK EPLIKFLNVI
LEKLLTLIVK PPSVHGQVIN VSAAAFDGLV DIVHVVSTFL DSDLHGRNTF LLSYIHYHCL
IKRYPSSDQD AVKDFHLYSR STSEIQAIHH ALSSFERAGS VRGTSDTASS AVGAQQNSRR
LPHEEIALQW AICAGPPRDF SLRHAWFFFE LIIQCMTQYL TASQRLHYPR AARFNERFIE
DLSTLVRTFT DDIVSSSARE MISLNTSLAF FFYDCLSLLD RGLVFQWIHT YCRKLNTKIV
TMLDPTQLMS LKLDCLRILS AHEHFFPLNL PFAQSQGYFR SLPASPSPSV ASNNSHNSGN
SSNSSFLQAS LELSSAFRQQ HFLVGLILSE LYAVFEVPNP SLHIKAVNIL RNLMSWHDAD
PRCGTKEARQ RLAHLYFPLI GIIMDSLAQL YEFVTPEIPK KGTQAIQQSV AMAIAGNNTV
VRRNSTEGRR PQLNAEATRH LLISFIWIVK SAEEHTLRGW WENLQGHRLA QLLEILQLTI
HCFEYSGPKT IHTRGHTGVQ REELKSMLGD AILGSIHVKN DFEKRRAGTL SARGSMTTGE
GLRYRKDQLW RPFPLSDTES LDAKNEAMLE GVLSAEVALT VLDNLDLVIQ IILSHPFLHD
QLGAAFKVLL HALGCSQSVQ VYETLFACQR SIVYKFPELL FEAETEYCAD LCLRLLSHCS
SAIAAVRSQA CASLYMLMRQ NFEIGNSFSR VKMQVTISLS SLVGTITDLN EDYLRRSLKT
ILTYADQDGE LKGSTFPEQV RDLVFNLHMI LSDTVKMKAY QEDPEMLMDL MYRIAKGYKN
SPDLRLTWLA NMAQKLSERG LYAETAQCRI HSAALVSEYL HLLEDKKYLP TGCVTFDKIS
SNILEESAIS DDVMSPNEEG ICTGKTFTES GLLALLDQAV DAFECAGMYE AVNEVYKIVI
PAVEVHHDYV QLAAIYKRLH EAFLKIDRMS GKRVFGTFFR VGFYGAKFGD LDGEEFVYKE
PVITMLPEIS HRLEAFYAEK FGVQYLEMVK DSNVIKKESL HPDKCYIQIT FVEPYFDRWE
LRHRQTFFQK NYNLRRFVYS TPFTMDGRSH GELHEQYKRK TILTTANAFP YVKTRIQVVA
RESIVLSPIE LAIEDMQKKT EELHAAIKAE PADAKMLQMV LQGSIGTTVN QGPLEVAAVF
LSHPHDQPMT PFQHKLRLCF KEFTRRCLEA LKKNKTLIAA DQKEYQRELE KNYQRFHDSI
KPMLAYNQEM LTQDELQNLS PILPS
//
