ID A0A1D1W8D2_RAMVA Unreviewed; 728 AA.
AC A0A1D1W8D2;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=RvY_19139-1 {ECO:0000313|EMBL:GAV09635.1};
GN Synonyms=RvY_19139.1 {ECO:0000313|EMBL:GAV09635.1};
GN ORFNames=RvY_19139 {ECO:0000313|EMBL:GAV09635.1};
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166 {ECO:0000313|EMBL:GAV09635.1, ECO:0000313|Proteomes:UP000186922};
RN [1] {ECO:0000313|EMBL:GAV09635.1, ECO:0000313|Proteomes:UP000186922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1 {ECO:0000313|EMBL:GAV09635.1,
RC ECO:0000313|Proteomes:UP000186922};
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAV09635.1}.
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DR EMBL; BDGG01000024; GAV09635.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D1W8D2; -.
DR STRING; 947166.A0A1D1W8D2; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.40.960.10; VSR Endonuclease; 1.
DR InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR PANTHER; PTHR33568; DNA POLYMERASE; 1.
DR PANTHER; PTHR33568:SF3; DNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF03175; DNA_pol_B_2; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000186922}.
FT DOMAIN 273..435
FT /note="DNA-directed DNA polymerase family B
FT mitochondria/virus"
FT /evidence="ECO:0000259|Pfam:PF03175"
SQ SEQUENCE 728 AA; 83450 MW; 397709076C346D30 CRC64;
MVHSRRISPE YGLTVIQGQV TVPPPPPPPP LMSVEAAAPM APAVSADTGE QVEEPTWTTE
HRRHPTASKW KKKNKFDVNR ELIRYCVQDV RTLKACAESL RQQFQDLSGG LCIFSCALTI
AGVCGYFWRC RMLREEEVEL VHRPSKRASS VKAQRWLRMM ADEDNVIEME TEVHIGSYYV
DGFDNDTSTV YEFYGCLHHG HDTHTRPETV HPWLKQSMGD LFRRTMARER QIIQLGYRVK
SIWECEFDRL MKSDAGLRRE LDSAVIVTRL EPRASLYGGR VNGTVLHHRC RAGEEIHYRD
VISEYPFVNK TKRYPVGKHT VITRNFVDDV TAYFGLLKIK ILPPRDLWIP VLPYRTSKLT
FPLCLCADTD QCTPCQHDDE ERALLGVWCS PEVEKAFERG YRVLQCYEMW HYSESRERLV
AEYIDHFLAL KTQASDWPAG VKTDAEKEAF LRDFLQTEGV QLDREKMEKT PGMRALAKLC
LKGKGKNLHP HSPSFLGKLA MRDNKPATIF IKDPHKFHEF LNSTQYNVTS FDLINEDVLQ
LSYTLQEEFV ETNPKTNVVL AAFTTAHARL HLLQYLEMCG RRTLYFDTDS IIYVCGDGDI
PLSTGNTLGC LTSELEEGEH IVEFCATGAK SYSYITNKGH AVCKVKGFTL TRCAGRVINF
HTMRDLLTVP GPQVLPVHYP FNIRRRKREL EIDAVPVVKK FQPTYTDKRV VDTATWASTP
YGYDMALL
//
