ID A0A1D2I3Z7_9ACTN Unreviewed; 1109 AA.
AC A0A1D2I3Z7;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=APS67_006635 {ECO:0000313|EMBL:ODA69210.1};
OS Streptomyces sp. AVP053U2.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1737066 {ECO:0000313|EMBL:ODA69210.1, ECO:0000313|Proteomes:UP000054731};
RN [1] {ECO:0000313|EMBL:ODA69210.1, ECO:0000313|Proteomes:UP000054731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AVP053U2 {ECO:0000313|EMBL:ODA69210.1,
RC ECO:0000313|Proteomes:UP000054731};
RA Olsen C.W., Carey S., Hinshaw L., Karasin A.I.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODA69210.1}.
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DR EMBL; LMTQ02000082; ODA69210.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D2I3Z7; -.
DR REBASE; 169705; Ssp53U2ORF6635P.
DR OrthoDB; 9776021at2; -.
DR Proteomes; UP000054731; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ODA69210.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054731};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 314..498
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 700..1051
FT /note="Type ISP restriction-modification enzyme LLaBIII C-
FT terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF18135"
FT REGION 739..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..755
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1109 AA; 122405 MW; 6C526F7F24FF29E1 CRC64;
MSGEGAAHEE QHESVNGLIS AFGKEVAAKL NGPGGEEEAL TSPVEGLLRG MAKRQNISAV
AYGQTSIKQL SARPDFAIGV GSKIIGHVEL KRPGKGVDPT AWQAKSHDRR QWEKIRVLPN
LLYTDGEQWA LFREGQQIGK TALLTGDLRE GNVVPADEQF AQLIAMFLSW APQQPASLSD
LVKRIAGLSR LLRDEVAEQL SREAEEEAQR AFTIVADDWK NLLFPDATPE SFADQYAQTV
TFALLLAQIE GIDLKTQPLP DVARKLGKRH ALMGKALAVL TDDALDDLRG VVGVLVQVIS
AVDPALFEDE TGDAYLHFYE GFLGAYDSKL RQKTGIYYTP SEVVRFMVGF TDAVLRSRLG
QSEGLASDEV TIIDPATGTG TFLINIIDRV AKDVESEYGS GIKPSKLRKL ADRLIGFEKQ
TGPYAVAELR ISHAFKAHEV GIADNAVRLH VTDTLDDPSL EVRLGFHYEA IAKHRRLANK
VKKTENIMVV IGNPPYRAGA KRAGLGRWVV EGNEVGSGPI LDQFRAVGSR HRDYVLHNLY
IYFWGWATWK AFAESPHDGA HKAPAGIVAF ITNAGYLDSQ GTAGMRSYLR KAADEGWIIG
LSPEGRQSNA STRIFQAMQE EVCIGVFVRH GDPNPDTPAH IRRLDVPPGR REEKFTWLES
LGIDGHQDGA EWQDCISEWQ APFQPGAGVA WEAMPTLNLL LPWTTSGNKN NRTWPVAPIQ
DVLIDRWKRL IKAPKNHKAA LMKATDDRTP EKAEPPLPGH EPGSLLPLSE ETDQSPKLIR
YGRMTFDRQW LIADRRVIDR PRPPLWFVQG PAQVYLSELH TEPGRPGPAV GFTALIPDNH
HFKGTQAGRI IPLHRDPHGL QANVTPGLLP AMEQAIGVPI TAEDLFAYIA GIAGHAGYSE
RYKEERTAGG VRVPLTRSPE LWQQVTEIGR RVLWLHTYGE RYSNPEAGRP QQTPRLPDGI
RPLCTAPIGE TSHGMPDTIE YDETTHTLTV GSGTIAPVSP EVWDYRIGGV RVVEKWFDFR
KREPDVERQT PLNDRNPETW PPEYTTELLS LLNVLGSLVA IEPEQERLLA AVDEGSLISV
DDLTTLGVLP VPPSAEKKPV IPRSTGQGH
//