ID A0A1D2I8T9_9ACTN Unreviewed; 727 AA.
AC A0A1D2I8T9;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=aminodeoxychorismate synthase {ECO:0000256|ARBA:ARBA00013139};
DE EC=2.6.1.85 {ECO:0000256|ARBA:ARBA00013139};
GN Name=pabB_2 {ECO:0000313|EMBL:ODA70884.1};
GN ORFNames=APS67_004888 {ECO:0000313|EMBL:ODA70884.1};
OS Streptomyces sp. AVP053U2.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1737066 {ECO:0000313|EMBL:ODA70884.1, ECO:0000313|Proteomes:UP000054731};
RN [1] {ECO:0000313|EMBL:ODA70884.1, ECO:0000313|Proteomes:UP000054731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AVP053U2 {ECO:0000313|EMBL:ODA70884.1,
RC ECO:0000313|Proteomes:UP000054731};
RA Olsen C.W., Carey S., Hinshaw L., Karasin A.I.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the anthranilate
CC synthase component I family. {ECO:0000256|ARBA:ARBA00005970}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODA70884.1}.
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DR EMBL; LMTQ02000032; ODA70884.1; -; Genomic_DNA.
DR RefSeq; WP_062190517.1; NZ_LMTQ02000032.1.
DR AlphaFoldDB; A0A1D2I8T9; -.
DR OrthoDB; 3518032at2; -.
DR Proteomes; UP000054731; Unassembled WGS sequence.
DR GO; GO:0046820; F:4-amino-4-deoxychorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01743; GATase1_Anthranilate_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005802; ADC_synth_comp_1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR006221; TrpG/PapA_dom.
DR NCBIfam; TIGR00553; pabB; 1.
DR NCBIfam; TIGR00566; trpG_papA; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF18; AMINODEOXYCHORISMATE SYNTHASE; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR Pfam; PF00117; GATase; 1.
DR PRINTS; PR00097; ANTSNTHASEII.
DR PRINTS; PR00099; CPSGATASE.
DR PRINTS; PR00096; GATASE.
DR SUPFAM; SSF56322; ADC synthase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:ODA70884.1};
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Reference proteome {ECO:0000313|Proteomes:UP000054731};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ODA70884.1}.
FT DOMAIN 4..185
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT DOMAIN 257..391
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 442..696
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT REGION 192..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 82
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 727 AA; 78014 MW; 11ABA97CF46F1BFF CRC64;
MRTLLVDNYD SFTYNLFHYL SRVNGREPEV IRNDDPAWRP GLLGSFDNVV LSPGPGTPHR
PADFGLCAGI AEEGRLPVLG VCLGHQGMAL AHGASVGRAP EPHHGRVCAV RHDGTGLFEG
LPQPLEVVRY HSLAVTDLPP ELEATAWSAD GVLMGLRHRT LPLWGVQFHP ESIGTREGHR
LLENFRRLTE EHDRAGGHRP VVTTGVPAQR RPPEADTATA VAPAPATAGG AAGGGSPRRL
RVVAERLRTR WDAEVAFDRL FRTGDHPFWL DSSRPGGRLG QLSVMGDASG PLARVASADV
ETGTVTVTEG GTTRVEQSPF LAWLERDLAG LSTEVPDLPF DFALGWVGCL GYELKAECDG
DAAHRSPDPD AVLVFADRAL VLDHRTDTTY LLALAEDGDE EPARSWLASA AGTLETLAGR
EPGPCEAPAS GGTGPVVLRH DRDAYLKLID VCQQEIAAGE TYEVCLTNMA ETDTDLDPWQ
AYRCLRRVSR APFAAFLHFG PMAVLSTSPE RFLRIDRHGV MESKPIKGTR PRGADPREDE
RLARDLAANE KDRAENLMIV DLVRHDLGRC AQVGSVVADP VFQVETYATV HQLVSTVRAR
LRPGLSPVAA VRAAFPGGSM TGAPKIRTMQ IIDRLEGGPR GVYSGAIGYF SLTGAVDLSI
VIRTVVLSGN RLRYGVGGAV IALSDPAAEF EETAVKAAPL LRLLGAAFPG REELAGEAVS
DVTPAGP
//
