ID A0A1D2IA54_9ACTN Unreviewed; 836 AA.
AC A0A1D2IA54;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=hsdM {ECO:0000313|EMBL:ODA71345.1};
GN ORFNames=APS67_004513 {ECO:0000313|EMBL:ODA71345.1};
OS Streptomyces sp. AVP053U2.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1737066 {ECO:0000313|EMBL:ODA71345.1, ECO:0000313|Proteomes:UP000054731};
RN [1] {ECO:0000313|EMBL:ODA71345.1, ECO:0000313|Proteomes:UP000054731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AVP053U2 {ECO:0000313|EMBL:ODA71345.1,
RC ECO:0000313|Proteomes:UP000054731};
RA Olsen C.W., Carey S., Hinshaw L., Karasin A.I.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the type-I restriction system S methylase
CC family. {ECO:0000256|ARBA:ARBA00010923}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODA71345.1}.
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DR EMBL; LMTQ02000027; ODA71345.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D2IA54; -.
DR REBASE; 169700; M.Ssp53U2ORF4513P.
DR Proteomes; UP000054731; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd16961; RMtype1_S_TRD-CR_like; 1.
DR Gene3D; 3.90.220.20; DNA methylase specificity domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000055; Restrct_endonuc_typeI_TRD.
DR InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF01420; Methylase_S; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF116734; DNA methylase specificity domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000313|EMBL:ODA71345.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054731};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000313|EMBL:ODA71345.1}.
FT DOMAIN 264..563
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 619..792
FT /note="Type I restriction modification DNA specificity"
FT /evidence="ECO:0000259|Pfam:PF01420"
SQ SEQUENCE 836 AA; 89935 MW; 7039BD90AA366201 CRC64;
MRSCCHMTAL PSITAIESAS AAVRAVERGS MRIRKYQQQQ LVSRAAIAEM AGVQRSAITN
WERRYTDFPS PTRAGGTDYY YLSDALTWLK GRSVPPRARR DDEGADATYA DRARTALVAA
SEAEAVEDLE AEGFPAAPGT AGDETDGEHL SPADILFREQ DEGQWGSGSR IGFLYLLFSL
VYLRWAQPRR WAVVRRAAAQ GQAGTHIHRF LPAVAQHVEQ TLAAQGVTSA MAVRLEDLAP
RSPQAIVRLL DKIESSGRGS FTELLGHHAL EAGLGSRDAF TPPGVARLLA ALLGSSAAQS
LYDPNGRGGE LLSAVLAARP EQGNEAGGGI PAVTIGSAHP GTRDLAAMNL MVHGARPELL
NLTGTTRPWT EGHRRRRADL VLTNPPFNVP AVPVDADWWT YGEPPASNAN LAWPQYAVMS
LNEGGRAAVL MPNSAATSSN LKEQRIRHAL VDRGAVECVI ALPAKMFSAT TISVNVWILK
PEAQERSSGE VLFIDASGLA TEVSRKLSVL EADDCALIAA AYHSWRGTGG NGAFLPDSRL
PCAAVRRDVV NAAGSSLRPA DYARPARRPN VDAEALTDPY GALLRSREEA GRADVLADSR
VAGFRQLGGG LGLPIDTAPD DWEWRNLGEL CELQAGPSPS LLPKDAYVLG GVVPVVQPKH
LRDRRVADAR GTAVPYDKAQ RLRRFALQEG DILCARTGTV GPVAHVRAGQ VGWLFGSNLI
RLHRFAPEVC PAYLLAYLSL SRTTEWIKSR SEKTTVPSIS KADLQALPVY LPTWSEQKRI
AGALGALDEQ IARHLEVAWA ATQVHKELAE QLVGLVALQG PTAPASADTF PERTSR
//