ID A0A1D2IIH3_9ACTN Unreviewed; 271 AA.
AC A0A1D2IIH3;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=16S/23S rRNA (Cytidine-2'-O)-methyltransferase TlyA {ECO:0000313|EMBL:ODA74224.1};
DE EC=2.1.1.226 {ECO:0000313|EMBL:ODA74224.1};
GN Name=tlyA {ECO:0000313|EMBL:ODA74224.1};
GN ORFNames=APS67_001348 {ECO:0000313|EMBL:ODA74224.1};
OS Streptomyces sp. AVP053U2.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1737066 {ECO:0000313|EMBL:ODA74224.1, ECO:0000313|Proteomes:UP000054731};
RN [1] {ECO:0000313|EMBL:ODA74224.1, ECO:0000313|Proteomes:UP000054731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AVP053U2 {ECO:0000313|EMBL:ODA74224.1,
RC ECO:0000313|Proteomes:UP000054731};
RA Olsen C.W., Carey S., Hinshaw L., Karasin A.I.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TlyA family.
CC {ECO:0000256|ARBA:ARBA00029460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODA74224.1}.
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DR EMBL; LMTQ02000006; ODA74224.1; -; Genomic_DNA.
DR RefSeq; WP_042168780.1; NZ_LMTQ02000006.1.
DR AlphaFoldDB; A0A1D2IIH3; -.
DR OrthoDB; 9784736at2; -.
DR Proteomes; UP000054731; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004538; Hemolysin_A/TlyA.
DR InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR047048; TlyA.
DR NCBIfam; TIGR00478; tly; 1.
DR PANTHER; PTHR32319; BACTERIAL HEMOLYSIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR32319:SF0; BACTERIAL HEMOLYSIN-LIKE PROTEIN; 1.
DR Pfam; PF01728; FtsJ; 1.
DR Pfam; PF01479; S4; 1.
DR PIRSF; PIRSF005578; TlyA; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:ODA74224.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054731};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182};
KW Transferase {ECO:0000313|EMBL:ODA74224.1}.
FT DOMAIN 7..74
FT /note="RNA-binding S4"
FT /evidence="ECO:0000259|SMART:SM00363"
SQ SEQUENCE 271 AA; 28576 MW; F222F613BB6F0C66 CRC64;
MAGVARRRLD AELVRRKLAR SREHAGQLIA AGRVSVGKTV ATKPATQVET AAAILVAEDA
GDPDYVSRGG HKLAGAFEAF VPQGLAVRGR RALDAGASTG GFTDVLLRAG AAHVVAVDVG
YGQLAWSLRN DERVTVKDRT NVRELTLEAI DGEPVDLVVG DLSFIPLGLV LPALKRCVRP
DADLVMMVKP QFEVGRERLG SGGVVRSPQL RAEAVRTVAA KAWELGLGAR GVTASPLPGP
SGNVEYFLWL RAGALELDPA DVDRAVAEGP R
//
