ID A0A1D2MPG2_ORCCI Unreviewed; 450 AA.
AC A0A1D2MPG2;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=Ocin01_11800 {ECO:0000313|EMBL:ODM94886.1};
OS Orchesella cincta (Springtail) (Podura cincta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Entomobryoidea; Orchesellidae; Orchesellinae; Orchesella.
OX NCBI_TaxID=48709 {ECO:0000313|EMBL:ODM94886.1, ECO:0000313|Proteomes:UP000094527};
RN [1] {ECO:0000313|EMBL:ODM94886.1, ECO:0000313|Proteomes:UP000094527}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Mixed pool {ECO:0000313|EMBL:ODM94886.1};
RX PubMed=27289101; DOI=10.1093/gbe/evw134;
RA Faddeeva-Vakhrusheva A., Derks M.F., Anvar S.Y., Agamennone V., Suring W.,
RA Smit S., van Straalen N.M., Roelofs D.;
RT "Gene Family Evolution Reflects Adaptation to Soil Environmental Stressors
RT in the Genome of the Collembolan Orchesella cincta.";
RL Genome Biol. Evol. 8:2106-2117(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the SINA (Seven in absentia) family.
CC {ECO:0000256|ARBA:ARBA00009119}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODM94886.1}.
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DR EMBL; LJIJ01000736; ODM94886.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D2MPG2; -.
DR STRING; 48709.A0A1D2MPG2; -.
DR OrthoDB; 3686344at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000094527; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049548; Sina-like_RING.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR013010; Znf_SIAH.
DR PANTHER; PTHR10315; E3 UBIQUITIN PROTEIN LIGASE SIAH; 1.
DR PANTHER; PTHR10315:SF117; IP10571P; 1.
DR Pfam; PF21362; Sina_RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS51081; ZF_SIAH; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00455}; Reference proteome {ECO:0000313|Proteomes:UP000094527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00455}.
FT DOMAIN 73..108
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 127..190
FT /note="SIAH-type"
FT /evidence="ECO:0000259|PROSITE:PS51081"
SQ SEQUENCE 450 AA; 50533 MW; 2E25F59B4A275997 CRC64;
MADPVDDTAD DFQVGWNTPY PTAPPSFMPG APELFTGGAA GPYPTIPGAP SELYPNIGFR
PDLISATKTY MECPVCFEIL TAPIYQCQNG HIICNNCINR IEFCGECRIP LGDSRIRNVA
LEYISQSMEV KCPNSTDGCE VLTTSGNLKI HLEVCDFRPI PLCSKHLGWT NCIEKVTASS
AINHLREVHQ VEEVEQAKFS LRLIAPPSAF QFAPGVTQEV YWNPLVITSA LDDADAVLKC
AVSREGYISF TCYLLGNNED YKKYRIKLEL DSSAKVARIE WTGSPLSYRQ QPDEIPNINT
FRLQLETLKE FCKPHSLDDG EEYSKLKVKV SVWKISDDDS PFRDCFRNAD GEEEPLEKVF
ISSRSPNSAN YSETMHHSDP EHYYSDLTCQ HCSTSLFGII YRCLQCPFAY YCKYCTERNV
HGMHLLLRIS SPEQQPLSEV VFECAAGELG
//
