ID A0A1D2MZ75_ORCCI Unreviewed; 760 AA.
AC A0A1D2MZ75;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Guanine nucleotide exchange factor VAV2 {ECO:0000313|EMBL:ODM98300.1};
GN ORFNames=Ocin01_08372 {ECO:0000313|EMBL:ODM98300.1};
OS Orchesella cincta (Springtail) (Podura cincta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Entomobryoidea; Orchesellidae; Orchesellinae; Orchesella.
OX NCBI_TaxID=48709 {ECO:0000313|EMBL:ODM98300.1, ECO:0000313|Proteomes:UP000094527};
RN [1] {ECO:0000313|EMBL:ODM98300.1, ECO:0000313|Proteomes:UP000094527}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Mixed pool {ECO:0000313|EMBL:ODM98300.1};
RX PubMed=27289101; DOI=10.1093/gbe/evw134;
RA Faddeeva-Vakhrusheva A., Derks M.F., Anvar S.Y., Agamennone V., Suring W.,
RA Smit S., van Straalen N.M., Roelofs D.;
RT "Gene Family Evolution Reflects Adaptation to Soil Environmental Stressors
RT in the Genome of the Collembolan Orchesella cincta.";
RL Genome Biol. Evol. 8:2106-2117(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODM98300.1}.
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DR EMBL; LJIJ01000365; ODM98300.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D2MZ75; -.
DR STRING; 48709.A0A1D2MZ75; -.
DR OMA; KNYTGAP; -.
DR OrthoDB; 2911406at2759; -.
DR Proteomes; UP000094527; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20810; C1_VAV; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000094527};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 143..329
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 362..469
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 480..529
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 619..723
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 740..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 87697 MW; E9920AC78595712A CRC64;
MWLTNINMNV SQYCFQFLCL RNIRTFLQVC KNVFELKDTD LFQPSMLFDL SDFGKVLFTL
SKLSTSPKAA ATGIEGFSAL GERAPILDEE MCQNLEELAS NGPEELFEED YYSVVVQTEE
DIYQDLCYID RQPRQPPVTL REKRDYVKGE LVETESNYID ALNMVKKNFM KPLTSILKED
DRKVIFFGIK RSNRALSSSS TPSISSSYPY GGGSHKTLGD VFVHWKEKFV IYGDYCANLT
RAQTLVEELC VKNEVVSLEV AKCEKDVKEG RFKLRDVLSV PMQRILKYHL LLQKLLDETS
REQHGYEEYK SIEKARDAMT DVAEFTNEVK RDSETLMIIR QIEGSIYDLK MPDGMELKDY
GRLQRDGELR IRGHDDNRLK SRYVFIFDKV MLMCKPTRSE QYSYKHSLCL QEYRVEDVPQ
TIRKSGIRDP RWSFCWNLVH HKEKNVYTMY AQTEEQKRRW IKAIEDALTN IQPEECRRTD
HHWTMHTFQK GANCSYCGKF LKGLFYQGYR CVRCDAGVHR DCISVLPRCG TVHPPELPPR
PPLLPIHAPA LVESVSVKSN TVFGWAAESS AFEDTDESVF HRHCPNNLNS PCTSNGMRLS
TTQPCHHYVN LNHLESYPWY AGEMDRDNAT SVLEMETNGT FLVRVRPASA VAAAAANDAI
YALSLKWNDQ VKHMKILVTR DEKLFYLSES RYFKSVVELI NWYQHNSLAE SFSGLDARLE
RPIERVTYGQ GIVHFDYNTT TQDSSTHQSL PLTQVPGTPS
//
