ID A0A1D2NBZ4_ORCCI Unreviewed; 1256 AA.
AC A0A1D2NBZ4;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Nardilysin {ECO:0000313|EMBL:ODN02783.1};
GN ORFNames=Ocin01_03937 {ECO:0000313|EMBL:ODN02783.1};
OS Orchesella cincta (Springtail) (Podura cincta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Entomobryomorpha; Entomobryoidea; Orchesellidae; Orchesellinae; Orchesella.
OX NCBI_TaxID=48709 {ECO:0000313|EMBL:ODN02783.1, ECO:0000313|Proteomes:UP000094527};
RN [1] {ECO:0000313|EMBL:ODN02783.1, ECO:0000313|Proteomes:UP000094527}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Mixed pool {ECO:0000313|EMBL:ODN02783.1};
RX PubMed=27289101; DOI=10.1093/gbe/evw134;
RA Faddeeva-Vakhrusheva A., Derks M.F., Anvar S.Y., Agamennone V., Suring W.,
RA Smit S., van Straalen N.M., Roelofs D.;
RT "Gene Family Evolution Reflects Adaptation to Soil Environmental Stressors
RT in the Genome of the Collembolan Orchesella cincta.";
RL Genome Biol. Evol. 8:2106-2117(2016).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODN02783.1}.
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DR EMBL; LJIJ01000096; ODN02783.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D2NBZ4; -.
DR STRING; 48709.A0A1D2NBZ4; -.
DR OMA; ICHFINE; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000094527; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000094527};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 298..401
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 444..629
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 634..903
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1206..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1256 AA; 143420 MW; 5892FB376A71DF36 CRC64;
MSQNRQPVKS FQPCMKCCRP RRCPESSDHS KSKKSSTPVP IPSTNTESCQ DIIKSPLDQR
LYKAITLGNG VRVMLISTFN VERQDGETDA TKTPCQVPEL ADFNKTYLGY NNPAAKVKCA
CPCDERKPCC GKGSKEEEAK RSILKDIVAN IKHTCCSANQ NQPRQSEEKK VSFDDNLNQF
RNAIERPSNP DDLITYQNTI FNELQKRADR FKHISEAKSR SRFEQSSVKL HEDKDRAAVD
SLAGEMHKLD SNGEADIIIE NRSSTHFETC DGDFIDETAP RSNRPQLTSP YNSDLDGTVY
LVIGTGYFDD PEDQPGLAHF CEHAVFLGSN KFPEPNQLFK LVLPYEGYVN AYTSGMMTTF
VTSASFRLFP LAVEILGDMV GFPLFPNSLV AAELEALDSE YSLRQDDTPK YFQLVGSLAK
NGHVMRKMDS GNMSTLTVPN FYRKLVEWRR IYYNPSRMTV ALEAPFPLDY LERLAISSFG
KIASAALPHI NKHLLISSPF EMNRFHQIYH VPSVYHSEFL SLHWAVEAKA WKNLRVKPLE
YLGAIIAHKS EGGLFRYLTT QGLATNVEAG CWESDVTKNH FTSVFSISVD MTEKGFKRQD
NILQAIFGYI QMLINNGPQK SFFQELQKQQ LDSFHYQAAE TSFNVGESCA RWMQYIPPKW
CLISPGLTAE FDDKTIQRYT ESLKVETANV IIFSKNYRAV EYLRNNNMEE FYNTTFAAFH
FPTELEEKMR RTKDEYATKF TLPVPNSLLL GTKCSRSREE DMLKKGTMLK IKGKLVVQYV
GRKMRVARGV LPQAKYTFWI GSPIASYVGA PEGNATKMII WSRLFNEIFK TKFYHASNAD
LQLETEISQG ELHIMLAGPH TMLPSLVEQV LELFNNFENI LDPIQFEVVR TAFIESLDNT
ILDNRFLAWD LFYYLWTNNH ELIFDHKRHA ERGLTFNSFI TFVSSFKIKM YIQGHLYGYV
TKSQGEKVAN ALTKLDYSPI DIRQYIVFRC LRLPLGERVI RVHTQNPHIH TSVVINSYQF
GQLTPVEETV VKFFTQTMSD AAFYQLRTEQ QLGYIIIIYA EVTFGVSSII VELVTQPKNF
TTEYCNECID KFLIDFFVTN LADQESFEEF SLGKPKLELP FPVIQNLFAS NLLQNPFTYR
KLSIQVVGTV DHTSPQTKTH EKAESPTQII PPSTKESRMD ETANSKVYRS QSLGGRTTID
RMRAAKKSLK MRDDSSVSSR GRKTSSGITT KVVNDIAKFK SSLMYYPKLY NNNNKN
//
