ID A0A1D2V890_9ASCO Unreviewed; 916 AA.
AC A0A1D2V890;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Sodium/calcium exchanger membrane region domain-containing protein {ECO:0000259|Pfam:PF01699};
GN ORFNames=ASCRUDRAFT_40283 {ECO:0000313|EMBL:ODV57848.1};
OS Ascoidea rubescens DSM 1968.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Ascoideaceae; Ascoidea.
OX NCBI_TaxID=1344418 {ECO:0000313|EMBL:ODV57848.1, ECO:0000313|Proteomes:UP000095038};
RN [1] {ECO:0000313|Proteomes:UP000095038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1968 {ECO:0000313|Proteomes:UP000095038};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., Labutti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
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DR EMBL; KV454503; ODV57848.1; -; Genomic_DNA.
DR RefSeq; XP_020044155.1; XM_020191016.1.
DR AlphaFoldDB; A0A1D2V890; -.
DR STRING; 1344418.A0A1D2V890; -.
DR GeneID; 30964652; -.
DR InParanoid; A0A1D2V890; -.
DR OrthoDB; 8346at2759; -.
DR Proteomes; UP000095038; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProt.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR31503:SF10; CATION_H+ EXCHANGER PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000095038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 139..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..834
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 854..874
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 453..637
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 743..899
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..729
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 916 AA; 102819 MW; D0E41C8B4C35F895 CRC64;
MDTHRLKRSN TLNTTYTSSG RNAIANANPN QNAASLQNFD LNGSDLQNES DYPPFLNLNT
NNDNQENSAD SESISSLESF TLRERQDAIN TTHPFGIRIW KPALYKKIRS VQRQADSDIH
QVNKNIGRKI TFWVSIGNII WFLTFGLILF ITCLIGFFFT LLINLFFLNL KKSSKNNSLN
YTFFIWKLGL YFLNPFGKVI YLYKDSNYID EDINEGITIR EYQRWRNNTD QRGLFFSSRG
MRNSSMGQTN VLNSNTNSLA VGPGNEITPL LSHQPSINGS VMGDGDGNYH SLSNDPPFNP
EADEHDYIDL ENGAANKVRF FGRGKWNVGR LAFYIYYYIF LAPVLYIISF LCWLLVFSIP
MSKVTTLLLN HLRKHPLAIF FKDDKNSSAK NINNSNILLC TYRFMGFHYY KYTVDGTNVF
LINLMFGVIF VIFDFYFLSE YLELELFLTH PSVIFGLCLA SVIPLAYFIG QAVASISAQS
SMGAGAVINA FFSTVVEVFL YCVALNQSKG KLVEGSLIGS ILGAVLLLPG LSMCAGAVKR
KTQRYNPKSA GVSSTMLLFS MVVMFAPSIF QQIFGAYEIT CTQCNSGEAI TSNDCRKCHF
SMPSLKYDIL YSQFLKPLTI FASIILFLAY CIGLWFTLRT HAALIWQTNV EREKEGGKSM
ANSTTLNSAG PEMGHSPNLL PLDETSGISS SIRRPSITRK ISSAIQNIAH TVKHEIEGPS
KEEEEAAAGG HDAPNWSRSK SSIILLGATV LYAIIAEILV DCVDVVLQEF PINPKFLGLT
VFALVPNTTE FLNAISFAMH GNVALSMEIG SAYVLQVILL QIPALVIYSV YNLMKIPSEE
IVGVNLENNY FTLLFPRWDL VISMISVYMF TYIYAEGKSN YFKGSLLILM YLVVIFGFYF
SDIVQDATSY TFHVFN
//
