ID A0A1D2WNF1_9EURY Unreviewed; 256 AA.
AC A0A1D2WNF1;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN ORFNames=A9505_04735 {ECO:0000313|EMBL:OEC97995.1};
OS Methanobrevibacter sp. A27.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=1860099 {ECO:0000313|EMBL:OEC97995.1, ECO:0000313|Proteomes:UP000094786};
RN [1] {ECO:0000313|EMBL:OEC97995.1, ECO:0000313|Proteomes:UP000094786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A27 {ECO:0000313|EMBL:OEC97995.1,
RC ECO:0000313|Proteomes:UP000094786};
RA Woodcroft B.J.;
RT "Validation of picogram- and femtogram-input DNA libraries for microscale
RT metagenomics.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC {ECO:0000256|RuleBase:RU366031}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC ChEBI:CHEBI:57845; EC=4.2.1.75;
CC Evidence={ECO:0000256|ARBA:ARBA00000783,
CC ECO:0000256|RuleBase:RU366031};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEC97995.1}.
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DR EMBL; LZPL01000016; OEC97995.1; -; Genomic_DNA.
DR RefSeq; WP_069574482.1; NZ_LZPL01000016.1.
DR AlphaFoldDB; A0A1D2WNF1; -.
DR Proteomes; UP000094786; Unassembled WGS sequence.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW ECO:0000256|RuleBase:RU366031}.
FT DOMAIN 22..244
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 256 AA; 28969 MW; D0E422CBC4F32A6E CRC64;
MSKPVVAITR PEDRAKKACD IVEKLGGEPF LAPTLDLEPV NSKSLKDLIK RKDELDWIIF
TSPTTIVSLN KFYPDFLGSL NCKLAVIGNK TGKLAEENGL KVDLIPEDFT AEGLIEEFKE
RKITNQIIGI PRTLSARPVL PEELEKMGNT VILAEAYKSL FPMDKKAVKE LISKIENKEI
DAITFTSPLT VENFFKIIEN KEKIAKLLSD NILTVCIGPI TAKVLKKYNI TYIHPDTYTV
PDMMELLFKK WREQNE
//
