ID   A0A1D2X1Z9_9EURY        Unreviewed;       161 AA.
AC   A0A1D2X1Z9;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=6-carboxy-5,6,7,8-tetrahydropterin synthase {ECO:0000313|EMBL:OED29968.1};
GN   ORFNames=NL43_05305 {ECO:0000313|EMBL:OED29968.1};
OS   Methanosphaera sp. WGK6.
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanosphaera.
OX   NCBI_TaxID=1561964 {ECO:0000313|EMBL:OED29968.1, ECO:0000313|Proteomes:UP000094737};
RN   [1] {ECO:0000313|EMBL:OED29968.1, ECO:0000313|Proteomes:UP000094737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WGK6 {ECO:0000313|EMBL:OED29968.1,
RC   ECO:0000313|Proteomes:UP000094737};
RX   PubMed=27022996; DOI=10.1038/ismej.2016.41;
RA   Hoedt E.C., Cuiv P.O., Evans P.N., Smith W.J., McSweeney C.S., Denman S.E.,
RA   Morrison M.;
RT   "Differences down-under: alcohol-fueled methanogenesis by archaea present
RT   in Australian macropodids.";
RL   ISME J. 10:2376-2388(2016).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR006113-2};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR006113-2};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OED29968.1}.
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DR   EMBL; JRWK01000008; OED29968.1; -; Genomic_DNA.
DR   RefSeq; WP_069593001.1; NZ_JRWK01000008.1.
DR   AlphaFoldDB; A0A1D2X1Z9; -.
DR   STRING; 1561964.NL43_05305; -.
DR   PATRIC; fig|1561964.3.peg.1052; -.
DR   OrthoDB; 6529at2157; -.
DR   Proteomes; UP000094737; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.479.10; 6-pyruvoyl tetrahydropterin synthase/QueD; 1.
DR   InterPro; IPR007115; 6-PTP_synth/QueD.
DR   InterPro; IPR038418; 6-PTP_synth/QueD_sf.
DR   PANTHER; PTHR12589:SF7; 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR   PANTHER; PTHR12589; PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR   Pfam; PF01242; PTPS; 1.
DR   PIRSF; PIRSF006113; PTP_synth; 2.
DR   SUPFAM; SSF55620; Tetrahydrobiopterin biosynthesis enzymes-like; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR006113-2};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR006113-2}.
FT   BINDING         18
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006113-2"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006113-2"
FT   BINDING         32
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006113-2"
SQ   SEQUENCE   161 AA;  18003 MW;  9EEABB5B65FE1EE5 CRC64;
     MKVNLDGIHT NLRFSAAHMV IGHESCGKIH GHSYIVDVEI SGEKSGQFGF VIDFKILKGI
     TRKICKQLDH RVLIPVNSPD LEITYEDDKT VEFKVLGDLE YKLPRSDVVL LPVVATTAEC
     LSEYITEAIV DELEDTTTLE YIELQVNEGI GQGASYHKKL N
//