ID A0A1D3D7Q0_9EIME Unreviewed; 597 AA.
AC A0A1D3D7Q0;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Xaa-Pro dipeptidase {ECO:0000256|ARBA:ARBA00044141};
DE EC=3.4.13.9 {ECO:0000256|ARBA:ARBA00044051};
DE AltName: Full=Imidodipeptidase {ECO:0000256|ARBA:ARBA00044351};
DE AltName: Full=Peptidase D {ECO:0000256|ARBA:ARBA00044252};
DE AltName: Full=Proline dipeptidase {ECO:0000256|ARBA:ARBA00044284};
GN ORFNames=cyc_02943 {ECO:0000313|EMBL:OEH79475.1};
OS Cyclospora cayetanensis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Cyclospora.
OX NCBI_TaxID=88456 {ECO:0000313|EMBL:OEH79475.1, ECO:0000313|Proteomes:UP000095192};
RN [1] {ECO:0000313|EMBL:OEH79475.1, ECO:0000313|Proteomes:UP000095192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHN_HEN01 {ECO:0000313|EMBL:OEH79475.1,
RC ECO:0000313|Proteomes:UP000095192};
RX PubMed=27129308; DOI=10.1186/s12864-016-2632-3;
RA Liu S., Wang L., Zheng H., Xu Z., Roellig D.M., Li N., Frace M.A., Tang K.,
RA Arrowood M.J., Moss D.M., Zhang L., Feng Y., Xiao L.;
RT "Comparative genomics reveals Cyclospora cayetanensis possesses coccidia-
RT like metabolism and invasion components but unique surface antigens.";
RL BMC Genomics 17:316-316(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + Xaa-L-Pro dipeptide = an L-alpha-amino acid + L-proline;
CC Xref=Rhea:RHEA:76407, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869,
CC ChEBI:CHEBI:60039, ChEBI:CHEBI:195196; EC=3.4.13.9;
CC Evidence={ECO:0000256|ARBA:ARBA00043793};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the peptidase M24B family. Eukaryotic-type
CC prolidase subfamily. {ECO:0000256|ARBA:ARBA00043990}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEH79475.1}.
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DR EMBL; JROU02000376; OEH79475.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D3D7Q0; -.
DR VEuPathDB; ToxoDB:cyc_02943; -.
DR VEuPathDB; ToxoDB:LOC34619710; -.
DR InParanoid; A0A1D3D7Q0; -.
DR Proteomes; UP000095192; Unassembled WGS sequence.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR007865; Aminopep_P_N.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000994; Pept_M24.
DR PANTHER; PTHR48392; -; 1.
DR PANTHER; PTHR48392:SF2; PEPTIDASE D; 1.
DR Pfam; PF05195; AMP_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SMART; SM01011; AMP_N; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000095192}.
FT DOMAIN 135..255
FT /note="Aminopeptidase P N-terminal"
FT /evidence="ECO:0000259|SMART:SM01011"
SQ SEQUENCE 597 AA; 65864 MW; DFB9E091F5AAE461 CRC64;
MENAVRGPPE EGASRLAVSC LREEMRSVLR DNQPEHKPWL RWPGTFEAIL DSDMQKTLRE
FLTSPLIHRE RIREVQTKFA SIAEASGVAS EGHAVFLQGG TSDEWSLYSL FRGVRVRCNS
TSSSVCSASC DLLSPSSAIF ACFAVVTLLR AFSLADCTKC PFRQEAFFQY LLGVNEPDLL
GVLILSRKEV LLFVPRISKD SLRFVGPPKS VAFYQERYGV SDVIPYERLD EVEVELKSRG
VHTLHVLHGI NSDSGSPAGP PNALKNFSAF RIDTAKLHGI LVESRLYKSE TEEKRTNSGC
ETRLVELHGE ALFKAFVGVA GGARHVAYDC ICCAGTHASI LHYGHAGRPN DGLIKDGDLL
LFDMGGDFSG YATDITFTFP ANGVFTEMQK AIYSAVLDAQ QAVLRRMKPG ERWTALHRLA
ERVILKHLKV TTSLHSNLQP LLHQRVRDRS TQRDRRMLAS PHSFSPSLFL RPSSSAVACL
PFLQTGGLDT HDVGGFTASS PPSNEPGLCY LRTTRILEEG MCITVEPGCY FVEHLLKKAA
ADPTQASLMN LPEIQKYVHV GGVRLEDDVI VTKTGILNLT VVPRAVADVE ELLRLAP
//
