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Database: UniProt
Entry: A0A1D3DQK2_9ACTN
LinkDB: A0A1D3DQK2_9ACTN
Original site: A0A1D3DQK2_9ACTN 
ID   A0A1D3DQK2_9ACTN        Unreviewed;       411 AA.
AC   A0A1D3DQK2;
DT   30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=J116_009000 {ECO:0000313|EMBL:OEJ94590.1};
OS   Streptomyces thermolilacinus SPC6.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1306406 {ECO:0000313|EMBL:OEJ94590.1, ECO:0000313|Proteomes:UP000095329};
RN   [1] {ECO:0000313|EMBL:OEJ94590.1, ECO:0000313|Proteomes:UP000095329}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SPC6 {ECO:0000313|EMBL:OEJ94590.1,
RC   ECO:0000313|Proteomes:UP000095329};
RX   PubMed=23868127;
RA   Chen X., Zhang B., Zhang W., Wu X., Zhang M., Chen T., Liu G., Dyson P.;
RT   "Genome Sequence of Streptomyces violaceusniger Strain SPC6, a Halotolerant
RT   Streptomycete That Exhibits Rapid Growth and Development.";
RL   Genome Announc. 1:0-0(2013).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00378,
CC         ECO:0000256|RuleBase:RU004355};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OEJ94590.1}.
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DR   EMBL; ASHX02000001; OEJ94590.1; -; Genomic_DNA.
DR   RefSeq; WP_023586758.1; NZ_ASHX02000001.1.
DR   AlphaFoldDB; A0A1D3DQK2; -.
DR   STRING; 1306406.J116_009000; -.
DR   eggNOG; COG1570; Bacteria.
DR   OrthoDB; 9802795at2; -.
DR   Proteomes; UP000095329; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   NCBIfam; TIGR00237; xseA; 1.
DR   PANTHER; PTHR30008; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR   PANTHER; PTHR30008:SF0; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 2.
DR   Pfam; PF13742; tRNA_anti_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00378};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW   Rule:MF_00378};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00378};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00378}.
FT   DOMAIN          12..106
FT                   /note="OB-fold nucleic acid binding"
FT                   /evidence="ECO:0000259|Pfam:PF13742"
FT   DOMAIN          129..348
FT                   /note="Exonuclease VII large subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02601"
FT   DOMAIN          308..398
FT                   /note="Exonuclease VII large subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02601"
SQ   SEQUENCE   411 AA;  44865 MW;  E32B05003A1977E0 CRC64;
     MALTTSAEAP LPVGQVSRLI GGWIDRLGAI WVEGQITQLS RRPGAGVVFM TLRDPSHDIS
     VSVTCYRQVF DAVADVVSEG ARVVVHAKPE WYAPRGQLSL RAAEIRPVGI GELLARLEQL
     KRSLAAEGLF AMERKRPLPF LPQLIGLVCG RASAAERDVL EVARRRWPAV RFEVRNVAVQ
     GVHAVPQVVR AVRELDRMDD VDVIVVARGG GSVEDLLPFS DEQLVRAVAE CRTPVVSAIG
     HEPDSPLLDL VADLRAATPT DAAKKVVPDV REELERVRSL RDRALRCVRG LLEREERGLA
     HALARPVMEH PQRMVEEREA QVEALLARSR RVLGHLLDRA DSELAHTHAR VVALSPAATL
     ERGYAVLQRP DGSVVRSPDE VAGDEELRAR VAAGAFTVRR VDGGGAVGTR P
//
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