ID A0A1D3DUP8_9ACTN Unreviewed; 384 AA.
AC A0A1D3DUP8;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Uroporphyrinogen-III synthase {ECO:0000313|EMBL:OEJ96045.1};
GN ORFNames=J116_017785 {ECO:0000313|EMBL:OEJ96045.1};
OS Streptomyces thermolilacinus SPC6.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1306406 {ECO:0000313|EMBL:OEJ96045.1, ECO:0000313|Proteomes:UP000095329};
RN [1] {ECO:0000313|EMBL:OEJ96045.1, ECO:0000313|Proteomes:UP000095329}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SPC6 {ECO:0000313|EMBL:OEJ96045.1,
RC ECO:0000313|Proteomes:UP000095329};
RX PubMed=23868127;
RA Chen X., Zhang B., Zhang W., Wu X., Zhang M., Chen T., Liu G., Dyson P.;
RT "Genome Sequence of Streptomyces violaceusniger Strain SPC6, a Halotolerant
RT Streptomycete That Exhibits Rapid Growth and Development.";
RL Genome Announc. 1:0-0(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEJ96045.1}.
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DR EMBL; ASHX02000001; OEJ96045.1; -; Genomic_DNA.
DR RefSeq; WP_023588424.1; NZ_ASHX02000001.1.
DR AlphaFoldDB; A0A1D3DUP8; -.
DR STRING; 1306406.J116_017785; -.
DR eggNOG; COG1587; Bacteria.
DR eggNOG; COG3710; Bacteria.
DR OrthoDB; 213853at2; -.
DR Proteomes; UP000095329; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR039793; UROS/Hem4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091}.
FT DOMAIN 277..370
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 277..370
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 384 AA; 40615 MW; 17C9C3D368E0297A CRC64;
MHEQQQENGP LAGFTVGVTA ARRADELGAL LQRRGAAVLH APALRIVPLA DDAELLDATR
QLVGSAPDIV VATTAIGFRG WLEAADGWGY GEELLACLRG VRVLARGPKV KGAVRAAGLT
EEWSPASDSM AEVLDRLLEQ GVSGQRVALQ LHGEPLPGFV EALRDAGAEV VVVPVYRWMP
PEDPAALDRL LDATVARTLD AVTFTSAPAA ASLLARAEHR GLRAELLDAL RHDVLAACVG
PVTAVPLQSH GVDTVQPARF RLGPLVQTLC QELPARARTL PVAGRRIEIR GHAVLVDGEL
RPVPPAGMSL LHALARRPGW VVSRADLLRA LPGAGRDEHA VETAMARLRT ALGAPKLIQT
VVKRGYRLAL DPTAEVPGQP AGEG
//
