ID A0A1D3THQ7_9APIC Unreviewed; 489 AA.
AC A0A1D3THQ7;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Vivapain-2, putative {ECO:0000313|EMBL:SCP04482.1};
GN Name=PocGH01_09021700 {ECO:0000313|EMBL:SCP04482.1};
GN ORFNames=POCGH01_09021700 {ECO:0000313|EMBL:SCP04482.1};
OS Plasmodium ovale (malaria parasite P. ovale).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=36330 {ECO:0000313|EMBL:SCP04482.1, ECO:0000313|Proteomes:UP000242942};
RN [1] {ECO:0000313|EMBL:SCP04482.1, ECO:0000313|Proteomes:UP000242942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PocGH01 {ECO:0000313|EMBL:SCP04482.1};
RG Pathogen Informatics;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; LT594590; SCP04482.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D3THQ7; -.
DR VEuPathDB; PlasmoDB:PocGH01_09021700; -.
DR VEuPathDB; PlasmoDB:POWCR01_090017000; -.
DR Proteomes; UP000242942; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 1.10.287.2250; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF1017; CLAN CA, FAMILY C1, CATHEPSIN L OR K-LIKE CYSTEINE PEPTIDASE; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242942};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 36..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 170..226
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 266..487
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 489 AA; 55710 MW; D2A4E4076B51C045 CRC64;
MEYHMEYSPN EAAKAEKESF VDNDVDRSFL KKKKNIFIIM SVSAICIFAC SVFYFTRPTS
RSDMFNNSSE KDVNDDYIIS SLLKSKSGKK FIVSKIEELI LLHDKNNNAQ VKTESSLVTR
GDDNNIKGIT TTSNNYKKRF GHLKVAKKSN VVNFLDTKFL MTNLESVNAF YIFMKEHGKK
YTSADEMEKK FIAFSKNIAK IDAHNKSNSL YIKGINQFAD LTYEEFKKKF LTLKKFSFNK
YRGILSHVVN YYDIINKYKP HDAVVDRVSY DWRLHGGVTP VKNQGNCGSC WAFSTVGVVE
SQYAIRKNLI ASISEQQLVD CSQQNNGCNG GFIELSFDDM INLGGLCSDK DYPYVADIPE
LCQIDSCTKT FTISSYLEVP QDKFKEALQF LGPISVSVAV SDDFAFYKEG IFDGECGDEP
NHAVMVVGYG MEEIYNTQTK RNEKHYYYII KNSWGNAWGE KGFIKLETDE YGYRKPCFLG
SDAVIALID
//
