ID A0A1D5NXL9_CHICK Unreviewed; 399 AA.
AC A0A1D5NXL9; A0A1D5NYH9; A0A1D5PBV1;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Homeobox B3 {ECO:0000313|Ensembl:ENSGALP00010034731.1};
GN Name=HOXB3 {ECO:0000313|Ensembl:ENSGALP00010034731.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010034731.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010034731.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010034731.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family.
CC {ECO:0000256|ARBA:ARBA00009107}.
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DR RefSeq; NP_990074.2; NM_204743.2.
DR RefSeq; XP_015154918.1; XM_015299432.1.
DR AlphaFoldDB; A0A1D5NXL9; -.
DR SMR; A0A1D5NXL9; -.
DR PaxDb; 9031-ENSGALP00000041773; -.
DR Ensembl; ENSGALT00010057098.1; ENSGALP00010034731.1; ENSGALG00010023428.1.
DR KEGG; gga:395502; -.
DR VEuPathDB; HostDB:geneid_395502; -.
DR GeneTree; ENSGT00940000159774; -.
DR InParanoid; A0A1D5NXL9; -.
DR Proteomes; UP000000539; Chromosome 27.
DR Bgee; ENSGALG00000043219; Expressed in ovary and 7 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0060324; P:face development; IEA:Ensembl.
DR GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0050767; P:regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021546; P:rhombomere development; IEA:Ensembl.
DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR025281; DUF4074.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664:SF11; HOMEOBOX PROTEIN HOX-B3; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF13293; DUF4074; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DNA_BIND 160..219
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 399 AA; 43458 MW; BC72BA3435E7CC80 CRC64;
MQKTTYYESS TLFGGYSYGS TNGFGYEGPQ QPFQPGSHVE NDFQRSACSL QSLGNTTQHA
KSKDLNGSCM RPSLPQEHHP PPTVSPPPNP TTNSTSSNSN NQSGSSKSAP SKANLSANAS
LTKQIFPWMK ESRQNSKQKS SSPSTETCSG EKSPPGSSAS KRARTAYTSA QLVELEKEFH
FNRYLCRPRR VEMANLLNLS ERQIKIWFQN RRMKYKKDQK SKGMGSSSGG PSPTGSPPQP
MQSSAGFMNA LHTMSSNYDA PSPPSFNKPH QNAYAMSTNY QNPIKGCPSQ QKYTNTAPEY
DPHVLQGNGV AYGTPSMQGS PVYVGGNYVD SLPTSGPSLY GLNHLPHHQA ANMDYSGPPQ
MPPSQHHGPC EPHPTYTDLS SHHASSQGRI QEAPKLTHL
//
